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Econazole


Pronunciation

 (e KONE a zole)


U.S. Brand Names

 Spectazole®


Synonyms

 Econazole Nitrate


Generic Available

 Yes


Canadian Brand Names

 Ecostatin®; Spectazole™


Use

 Topical treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), tinea corporis (ringworm), tinea versicolor, and cutaneous candidiasis


Pregnancy Risk Factor

 C


Pregnancy Implications

 Do not use during the 1st trimester of pregnancy, unless essential to a patient's welfare; use during the second and third trimesters only if clearly needed


Lactation

 Excretion in breast milk unknown


Contraindications

 Hypersensitivity to econazole or any component of the formulation


Warnings/Precautions

 Discontinue drug if sensitivity or chemical irritation occurs; not for ophthalmic or intravaginal use


Adverse Reactions

1% to 10%: Genitourinary: Vulvar/vaginal burning

<1% (Limited to important or life-threatening): Vulvar itching, soreness, edema, or discharge; polyuria; burning or itching of penis of sexual partner


Drug Interactions

 Inhibits CYP2E1 (weak)

No drug interaction data reported


Mechanism of Action

 Alters fungal cell wall membrane permeability; may interfere with RNA and protein synthesis, and lipid metabolism


Pharmacodynamics/Kinetics

Absorption: <10%

Metabolism: Hepatic to more than 20 metabolites

Excretion: Urine; feces (<1%)


Dosage

 Children and Adults: Topical:

Tinea pedis, tinea cruris, tinea corporis, tinea versicolor: Apply sufficient amount to cover affected areas once daily

Cutaneous candidiasis: Apply sufficient quantity twice daily (morning and evening)

Duration of treatment: Candidal infections and tinea cruris, versicolor, and corporis should be treated for 2 weeks and tinea pedis for 1 month; occasionally, longer treatment periods may be required


Patient Education

 For external use only. Apply exactly as directed and for the length of time prescribed. Report if conditions worsens or persists or if infection occurs. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. Consult prescriber if breast-feeding.


Nursing Implications

 Candidal infections and tinea cruris, versicolor, and corporis should be treated for 2 weeks and tinea pedis for 1 month; occasionally, longer treatment periods may be required


Dental Health: Effects on Dental Treatment

 No significant effects or complications reported


Dental Health: Vasoconstrictor/Local Anesthetic Precautions

 No information available to require special precautions


Mental Health: Effects on Mental Status

 None reported


Mental Health: Effects on Psychiatric Treatment

 None reported


Dosage Forms

 Cream, topical, as nitrate: 1% (15 g, 30 g, 85 g)


International Brand Names

 Amicel® (RO); Chemionazolo® (IT); Dermazole® (AU, HK, SG); Dermazol® (FR); Ecalin® (HR, RU, SI); Ecanol® (IN); Ecodax® (RU); Ecodergin® (IT); Ecoderm® (ZA); Ecomi® (IT, RO); Econal® (ZA); Econazolo Merck Generics® (IT); Econazolo Pliva® (IT); Econ® (RO, TH); Ecostatin-1® (GB); Ecostatin® (CA, GB, IE, NZ); Ecosteril® (IT); Ecotam® (ES); Ecozol® (BD); Ecreme (NZ); Epi-Pevaryl® (DE); Epi-Pevaryl P.v.® (DE); Fongéryl® (FR); Ganazolo® (IT); Gyno-Coryl® (JO, LB); Gyno-Pevaryl® (AT, BD, BE, BG, CH); Gyno Pevaryl® (CR); Gyno-Pevaryl® (CY, CZ, DE); Gyno Pevaryl® (DO); Gyno-Pevaryl® (EG, ES, FR, GB); Gyno Pevaryl® (GT); Gyno-Pevaryl® (HK); Gyno Pevaryl® (HN); Gyno-Pevaryl® (HU, IE, IL, JO, LB, LU, MT, NZ); Gyno Pevaryl® (PA); Gyno-Pevaryl® (PL, PT, RO, SG); Gyno Pevaryl® (SV); Gyno-Pevaryl® (SY); Gyno Pevaryl® (YU); Gyno-Pevaryl® (ZA); Gynoryl® (EC); Ifenec® (IT); Italconazol® (EC); Micocide® (AR); Micoespec® (ES); Mico Fitex® (AR); Micolis® (AR, CL); Micos® (IT); Micostyl® (BR, MX); Mitekol® (SI); Novo-Paramicon® (AR); Pevalip® (AT); Pevaryl® (AT, AU, BD, BE, BG, CH, CY, CZ, DK, ES, FI, FR, GB, HK, HU, IE, IL, IT, JO, LU, MT, NL, NO, NZ, PL, PT, RO, SE, YU, ZA); Pevaryl G® (HU); Pevaryl-Hautschampoo® (AT, BE); Pevaryl Lipogel® (AT, BE, CH, CR, DO, GT, HN, MX, PA, PL, SV); Pevaryl lotion® (FR); Pevaryl P.V.® (HK, PL); Pevazol® (PL); Pevisone® (BG); Polinazolo® (IT); Sebolith® (CH); Sinamida Econazol® (AR); Spectazole™ (CA)


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