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Goldenseal

Also listed as: Eye balm; Ground raspberry; Indian paint; Indian turmeric

• Overview
• Plant Description
• What's It Made Of?
• Medicinial Uses and Indications
• Available Forms
• How to Take It
• Precautions
• Possible Interactions
• Supporting Research

Overview

Goldenseal ( Hydrastis canadensis ) was originally introduced to early American settlers by Native American tribes, who used it primarily for skin problems and as a wash for sore eyes. A member of the buttercup family, goldenseal was also commonly used to produce a golden-yellow dye.

In the early 1900s, tonics containing goldenseal became popular for the treatment of upset stomach and menstrual disorders. By the mid-1990s, a rumor began to circulate that drinking goldenseal tea would allow illicit drug users (marijuana) to avoid detection. Although several studies have reported that goldenseal does not alter drug testing, one study did find that goldenseal tea masked the detection of amphetamines and THC (found in marijuana). In part due to the drug masking publicity, the popularity of goldenseal soared and the herb became severely over harvested. In 1997, the Convention on International Trade in Endangered Species of Wild Fauna and Flora reported that goldenseal is at risk of becoming an endangered species. As a result, the international trade of goldenseal continues to be closely controlled and monitored.

Plant Description

Goldenseal is a small plant with a single hairy stem. It has two five-lobed, jagged leaves, small flowers, and raspberry-like fruit. The bitter-tasting rhizome, or root, is a bright yellow-brown in color, twisted, and wrinkled. Goldenseal can be found growing wild in rich, shady soil in the northern United States, but is now grown mostly on farms.

What's It Made Of?

Goldenseal contains a compound called berberine that kills many types of bacteria, including the ones that cause diarrhea. Berberine has also been shown to kill a wide range of other types of germs, such as those that cause candida (yeast) infections, viruses, and various parasites such as tapeworms and Giardia. Berberine may also activate white blood cells, making them more effective at fighting infection and strengthening the immune system. For these reasons, berberine is used as an antibiotic and disinfectant, both externally and internally. Berberine may also be useful in heart failure and malaria.

Medicinial Uses and Indications

Today, goldenseal is marketed as a tonic to aid digestion, sooth upset stomach, and as an antibacterial and antiviral agent. It is considered a natural antibiotic and is most often combined with echinacea in preparations designed to strengthen the immune system. Many professional herbalists recommend goldenseal in herbal remedies for hay fever (also called allergic rhinitis), colds, and the flu. Goldenseal is considered a useful antiseptic (which is why some herbalists use it topically to disinfect cuts and scrapes) and astringent. It is commonly used to treat severak skin, eye, and mucous membrane inflammatory and infectious conditions (such as sinusitis, conjunctivitis, and urinary tract infections). It is also available in mouthwashes for sore throats and canker sores.

Goldenseal has not been thoroughly investigated in scientific studies, but some trials have looked at berberine, one of the active compounds in goldenseal. Berberine is a substance widely used in Traditional Chinese Medicine to treat dysentery and infectious diarrhea. Berberine may be effective in humans for malaria, heart failure, and various types of infections, including upper respiratory problems.

Laboratory studies suggest that this substance has antibacterial and immune-enhancing properties and may also have cardiovascular benefits. Berberine has been shown to dilate blood vessels and, therefore, may prove useful in the treatment of irregular heartbeat and heart failure. However, oral doses of goldenseal contain only trace amounts of berberine, so it is unlikely that the herb confers the same benefits as berberine alone. It is possible that topical goldenseal preparations and goldenseal extracts containing high concentrations of berberine may be as effective as berberine alone, but further studies are needed to investigate this possibility before any recommendations can be made.

Available Forms

Goldenseal supplements are available as tablets and capsules (containing the powdered root), liquid extracts, and glycerites (low-alcohol extracts). Goldenseal is commonly found in combination with the herb echinacea.

How to Take It

Pediatric

Adjust the recommended adult dose to account for the child's weight. Most herbal dosages for adults are calculated on the basis of a 150 lb (70 kg) adult. Therefore, if the child weighs 50 lb (20 - 25 kg), the appropriate dose of goldenseal for this child would be 1/3 of the adult dosage.

Adult

• Capsules or tablets: 500 - 2,000 mg, up to 3 times daily
• Standardized extract: 30 - 120 mg, up to 3 times daily
• Tinctures (1:5): 3 - 7 mL, daily
• For disinfecting cuts, scrapes, boils, and acne: Place goldenseal liquid extract on a clean cloth, and press the cloth gently on the affected area.
• For earaches: Mix with olive oil and use as eardrops.
• For sore throat, gums, or mouth, make a mouthwash as follows: In one cup of warm water, mix 1/4 tsp salt and 1/2 tsp (or the contents of one capsule) of goldenseal powder. (It will not dissolve completely.) Rinse and expectorate (spit out).
• For vaginal irritation, make a goldenseal douche as follows: Mix 1/4 tsp salt and 1/2 tsp (or the contents of one capsule) of goldenseal powder in 1 cup of warm water. Let the mixture settle, and strain out any suspended particles before using it. (Keep the mixture as clean as you can.) Over-douching can make you more susceptible to certain kinds of vaginal infections. See your health care provider if your symptoms do not improve after a few days.
• For eye infections and irritations, make an eyewash as follows: Use one cup of sterile water with 1/4 tsp salt and 1/2 tsp goldenseal (or the contents of one capsule), and strain out all particles. Discard if the solution becomes cloudy, which indicates bacterial growth or spoilage.

Precautions

The use of herbs is a time-honored approach to strengthening the body and treating disease. Herbs, however, contain components that can trigger side effects and interact with other herbs, supplements, or medications. For these reasons, herbs should be taken with care, under the supervision of a health care provider qualified in the field of botanical medicine.

Pregnant or breastfeeding women as well as those with high blood pressure should avoid using goldenseal.

Goldenseal can irritate the skin, mouth, throat, and vagina. It can also reduce the number of "good" bacteria in the digestive system, which can cause nausea and diarrhea. Goldenseal may also cause an increased sensitivity to sunlight.

Goldenseal may interfere with the metabolism and effectiveness of certain medications. Do not use goldenseal if you are taking prescription or non-prescription medications unless you are under the supervision of a qualified health care provider.

Possible Interactions

A few studies report interactions between berberine (a major component of goldenseal) and prescription or non-prescription medicines. One study reported that berberine may decrease the effectiveness of tetracycline antibiotics. Other laboratory studies report that berberine may alter liver metabolism, potentially affecting the levels of medications processed in the liver. Several studies actually report that goldenseal itself does not interact with medicines metabolized by the liver (including an antiviral drug used in HIV infection and digoxin). However, if you are taking prescription or non-prescription medications, do not use goldenseal unless you are under the supervision of a qualified health care provider.

Supporting Research

Abidi P, Chen W, Kraemer FB, et al. The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms. J Lipid Res . 2006;47(10):2134-47.

Brinker F. Herb Contraindications and Drug Interactions . 2nd ed. Sandy, OR: Eclectic Medical Publications; 1998:78.

Hwang BY, Roberts SK, Chadwick LR, et al. Antimicrobial constituents from goldenseal (the Rhizomes of Hydrastis canadensis) against selected oral pathogens. Planta Med . 2003;69(7):623-7.

Inbaraj JJ, Kukielczak BM, Bilski P, et al. Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine. Chem Res Toxicol . 2006;19(6):739-44.

Li H, Miyahara T, Tezuka Y, et al. Effect of berberine on bone mineral density in SAMP6 as a senile osteoporosis model. Biol Pharm Bull . 2003;26(1):110-1.

Khin-Muang-U, Myo-Khin, Nyunt-Nyunt-Wai, et al. Clinical trial of berberine in acute watery diarrhea. Br Med J 1985; 291:1601-5.

Lau CW, Yao XQ, Chen ZY, et al. Cardiovascular actions of berberine. [review]. Cardiovasc Drug Rev . 2001;19(3):234-244.

LaValle JB, Krinsky DL, Hawkins EB, et al. Natural Therapeutics Pocket Guide . Hudson, OH:LexiComp; 2000: 448-449.

Mahady GB, Pendland SL, Stoia A, et al. In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis. Phytother Res . 2003;17(3):217-21.

Palanisamy A, Haller C, Olson KR. Photosensitivity reaction in a woman using an herbal supplement containing ginseng, goldenseal, and bee pollen. J Toxicol Clin Toxicol . 2003;41(6):865-7.

Periera da Silva A, Rocha R, Silva CM, et al. Antioxidants in medicinal plant extracts. A research study of the antioxidant capacity of Crataegus, Hamamelis and Hydrastis. Phytother Res . 2000;14(8):612-616.

Rabbani GH, Butler T, Knight J, et al. Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae . J Infect Dis 1987; 155:979-84.

Rotblatt M, Ziment I. Evidence-Based Herbal Medicine . Philadelphia, PA: Hanley & Belfus, Inc; 2002:221-225.

Sandhu RS, Prescilla RP, Simonelli TM, et al. Influence of goldenseal root on the pharmacokinetics of indinavir. J Clin Pharmacol . 2003;43(11):1283-8.

Scazzocchio F, Cometa MF, Tomassini L, et al. Antibacterial activity of Hydrastis canadensis extract and its major isolated alkaloids. Planta Med . 2001;67(6):561-564.

Swanston-Flatt SK, et al. Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice. Acta Diabetol Lat . 1989;26:51–55.

Weber HA, Zart MK, Hodges AE, et al., Chemical comparison of goldenseal (Hydrastis canadensis L.) root powder from three commercial suppliers. J Agric Food Chem . 2003;51(25):7352-8.

White L, Mavor S. Kids, Herbs, Health . Loveland, Colo: Interweave Press; 1998:22, 32.

Wu AH, Forte E, Casella G, et al. CEDIA for screening drugs of abuse in urine and the effect of adulterants. J Forensic Sci 1995;40(4):614-618.

• Review Date: 1/24/2007
• Reviewed By: Ernest B. Hawkins, MS, BSPharm, RPh, Health Education Resources; and Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.

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