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Potassium

Overview:

Potassium is a mineral that helps the kidneys function normally. It is also an electrolyte, a substance that conducts electricity in the body, along with sodium, chloride, calcium, and magnesium. Potassium is crucial to heart function and plays a key role in skeletal and smooth muscle contraction, making it important for normal digestive and muscular function, too. A heart-healthy diet includes potassium from fruits, vegetables, and legumes.

Having too much potassium in the blood is called hyperkalemia; having too little is known as hypokalemia. Keeping the right potassium balance in the body depends on the amount of sodium and magnesium in the blood. Too much sodium -- common in Western diets that use a lot of salt -- may increase the need for potassium. Diarrhea, vomiting, excessive sweating, malnutrition, malabsorption syndromes (such as Crohn's disease) can also cause potassium deficiency, as wells as use of a kind of heart medicine called loop diuretics.

Mose people get all of the potassium they need from a healthy diet rich in vegetables and fruits. Older people have a greater risk of hyperkalemia because our kidneys get rid of potassium less efficiently as we age. Older people should be careful when taking medication that may affect potassium levels, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and ACE inhibitors (see section on Interactions).

Whatever your age, talk to your doctor before taking potassium supplements.

Hypokalemia

The most important use of potassium is to treat the symptoms of hypokalemia (low potassium), which include weakness, lack of energy, muscle cramps, stomach disturbances, an irregular heartbeat, and an abnormal EKG (electrocardiogram, a test that measures heart function). Hypokalemia is usually caused by the body losing too much potassium in the urine or intestines; it's rarely caused by a lack of potassium in the diet. Hypokalemia can be life-threatening and should always be treated by a doctor.

High Blood Pressure

Some studies have linked low levels of potassium in the diet with high blood pressure. And there is some evidence that potassium supplements might cause a slight drop in blood pressure. But not all studies agree -- two large studies found no effect on blood pressure. It may be that taking potassium only helps lower blood pressure if you're not getting enough of this mineral to start with. Before taking potassium or any supplement for high blood pressure, talk to your doctor.

Stroke

People who get a lot of potassium in their diet have a lower risk of stroke. However, potassium supplements don't seem to have the same benefit.

Inflammatory Bowel Disease (IBD)

People with IBD (ulcerative colitis or Crohn's disease) often have trouble absorbing nutrients from their intestine, and may have low levels of potassium and other important nutrients. If you have IBD, your doctor may check your potassium levels and recommend a supplement.

Dietary Sources:

Good sources of potassium include bananas, citrus juices (such as orange juice), avocados, cantaloupes, tomatoes, potatoes, lima beans, flounder, salmon, cod, chicken, and other meats.

Available Forms:

Several potassium supplements are on the market, including potassium acetate, potassium bicarbonate, potassium citrate, potassium chloride, and potassium gluconate.

Potassium can also be found in multivitamins.

How to Take It:

Potassium supplements, other than the small amount included in a multivitamin, should be taken only under your doctor's supervision. Do not give potassium supplements to a child unless your doctor tells you to.

The recommended daily intakes of dietary potassium are listed below:

Pediatric

  • Infants birth to 6 months: 500 mg or 13 mEq
  • Infants 7 months to 12 months: 700 mg or 18 mEq
  • Children 1 year: 1,000 mg or 26 mEq
  • Children 2 - 5 years: 1,400 mg or 36 mEq
  • Children 6 - 9 years: 1,600 mg or 41 mEq
  • Children over 10 years: 2,000 mg or 51 mEq

Adult

  • 2,000 mg or 51 Meq, including for pregnant and nursing women

Precautions:

Because of the potential for side effects and interactions with medications, you should take dietary supplements only under the supervision of a knowledgeable health care provider.

Older adults should talk to their doctor before taking potassium supplements.

Side effects can include diarrhea and nausea. At higher doses, muscle weakness, slowed heart rate, and abnormal heart rhythm may occur.

People with hyperkalemia or kidney disease should not take potassium supplements.

People who take ACE inhibitors, potassium-sparing diuretics, or the antibiotic trimethoprim and sulfamethoxazole (Bactrim, Septra) should not take potassium.

Possible Interactions:

If you are being treated with any of the following medications, you should not use potassium without first talking to your health care provider.

The following medications may cause potassium levels to rise:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs): People who have poor kidney function and take NSAIDs are at higher risk.
  • ACE inhibitors: These drugs treat high blood pressure, heart disease, diabetes, some chronic kidney diseases, migraines, and scleroderma. People who take ACE inhibitors and also take NSAIDs, potassium-sparing diuretics, or salt substitutes may be particularly vulnerable to hyperkalemia (too much potassium). A rise in potassium from ACE inhibitors may also be more likely in people with poor kidney function and diabetes. ACE inhibitors include
    • Benazepril (Lotensin)
    • Captopril (Capoten)
    • Enlapril (Vasotec)
    • Fosinopril (Monopril)
    • Lisinopril (Zestril)
    • Moexipril (Univasc)
    • Peridopril (Aceon)
    • Ramipril (Altace)
    • Trandolapril (Mavik)
  • Heparin (used for blood clots)
  • Cyclosporine (used to suppress the immune system)
  • Trimethoprimand sulfamethoxazole, called Bactrim or Septra (an antibiotic)
  • Beta-blockers: Used to treat high blood pressure, glaucoma, migraines
    • Atenolol (Tenormin)
    • Metoprolol (Lopressor, Toprol-XL)
    • Propranolol (Inderal)

The following medications may cause potassium levels to decrease:

  • Thiazide diuretics
    • Hydrochlorothiazide
    • Chlorothiazide (Diuril)
    • Indapamide (Lozol)
    • Metolzaone (Zaroxolyn)
  • Loop diuretics
    • Furosemide (Lasix)
    • Bumetanide (Bumex)
    • Torsemide (Demadex)
    • Ethacrynic acid (Edecrin)
  • Corticosteroids
  • Amphotericin B (Fungizone)
  • Antacids
  • Insulin
  • Fluconazole (Diflucan): Used to treat fungal infections
  • Theophylline (TheoDur): Used for asthma
  • Laxatives

If you are taking any of these medications, it is important for your doctor to test your potassium levels to see whether or not you need a supplement. Do not start taking a supplement on your own.

Other potential interactions include:

Digoxin -- Low blood levels of potassium increase the likelihood of toxic effects from digoxin, a medication used to treat abnormal heart rhythms and heart failure. Your doctor will test your potassium levels to make sure they stay normal.

  • Reviewed last on: 10/1/2007
  • Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.

Supporting Research

Alappan R, Perazella MA, Buller GK, et al. Hyperkalemia in hospitalized patients treated with trimethoprim-sulfamethoxazole. Ann Intern Med. 1996;124(3):316-320.

Appel LJ. Nonpharmacologic therapies that reduce blood pressure: a fresh perspective. Clin Cardiol. 1999;22(Suppl. III):III1-III5.

Apstein C. Glucose-Insulin-Potassium for acute myocardial infraction: remarkable results from a new prospective, randomized trial. Circ. 1998;98:2223-2226.

Apstein CS, Opie Lh. Glucose-insulin-potassium (GIK) for acute myocardial infarction: a negative study with a positive value. Cardiovasc Drugs Ther. 1999;13(3):185-189.

Ascherio A, Rimm EB, Hernan MA, et al. Intake of potassium, magnesium, calcium, and fiber and risk of stroke among U.S. men. Circ. 1998;98:1198-1204.

Brancati FL, Appel LJ, Seidler AJ, Whelton PK. Effect of potassium supplementation on blood pressure in African Americans on a low-potassium diet. Arch Intern Med. 1996;156:61-72.

Brater DC. Effects of nonsteroidal anti-inflammatory drugs on renal function: focus on cyclooxygenase-2-selective inhibition. Am J Med. 1999;107(6A):65S-70S.

Burgess E, Lewanczuk R, Bolli P, et al. Lifestyle modifications to prevent and control hypertension. 6. Recommendations on potassium, magnesium and calcium. Canadian Hypertension Society, Canadian Coalition for High Blood Pressure Prevention and Control, Laboratory Centre for Disease Control at Health Canada, Heart and Stroke Foundation of Canada. CMAJ. 1999;160(9 Suppl):S35-S45.

Cappuccio EP, MacGregor GA. Does potassium supplementation lower blood pressure? A meta-analysis of published trials. J Hypertens. 1991;9:465-473.

Chiu TF, Bullard MJ, Chen JC, Liaw SJ, Ng CJ. Rapid life-threatening hyperkalemia after addition of amiloride HCL/hydrochlorothiazide to angiotensin-converting enzyme inhibitor therapy. Ann Emerg Med. 1997;30(5):612-615.

Dickinson HO, Nicolson DJ, Campbell F, Beyer FR, Mason J. Potassium supplementation for the management of primary hypertension in adults. Cochrane Database Syst Rev. 2006 Jul 19;3:CD004641. Review.

Hermansen K. Diet, blood pressure and hypertension. Br J Nutr. 2000:83(Suppl 1):S113-119.

Heyka R. Lifestyle management and prevention of hypertension. In: Rippe J, ed. Lifestyle Medicine. 1st ed. Malden, Mass: Blackwell Science; 1999:109-119.

Houston MC. Treatment of hypertension with nutraceuticals, vitamins, antioxidants and minerals. Expert Rev Cardiovasc Ther. 2007 Jul;5(4):681-91.

Howes LG. Which drugs affect potassium? Drug Saf. 1995;12(4):240-244.

Iso H, Stampfer MJ, Manson JE, et al. Prospective study of calcium, potassium, and magnesium intake and risk of stroke in women. Stroke. 1999;30(9):1772-1779.

Joint National Committee. Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. Arch Int Med. 1997;157:2413-2446.

Kendler BS. Recent nutritional approaches to the prevention and therapy of cardiovascular disease. Prog Cardiovasc Nurs. 1997;12(3):3-23.

Krauss RM, Eckel RH, Howard B, et al. AHA dietary guidelines. Revision 2000: A statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Circulation. 2000;102:2284-2299.

Matsui H, Shimosawa T, Uetake Y, Wang H, Ogura S, Kaneko T, et al. Protective effect of potassium against the hypertensive cardiac dysfunction: association with reactive oxygen species reduction. Hypertension. 2006 Aug;48(2):225-31.

Myers VH, Champagne CM. Nutritional effects on blood pressure. Curr Opin Lipidol. 2007 Feb;18(1):20-4.

Matsumura M, Nakashima A, Tofuku Y. Electrolyte disorders following massive insulin overdose in a patient with type 2 diabetes. Intern Med. 2000;39(1):55-57.

Newnham DM. Asthma medications and their potential adverse effects in the elderly: recommendations for prescribing. Drug Saf. 2001;24(14):1065-1080.

O'Shaughnessy KM. Role of diet in hypertension management. Curr Hypertens Rep. 2006 Aug;8(4):292-7. Review.

Perazella MA. Trimethoprim-induced hyperkalemia: clinical data, mechanism, prevention and management. Drug Saf. 2000;22(3):227-236.

Perazella M, Mahnensmith R. Hyperkalemia in the elderly. J Gen Intern Med. 1997;12:646-656.

Physicians' Desk Reference. 55th ed. Montvale, NJ: Medical Economics Co., Inc.; 2001:1418-1422, 2199-2207.

Poirier TI. Reversible renal failure associated with ibuprofen: case report and review of the literature. Drug Intel Clin Pharm. 1984;18(1):27-32.

Preston RA, Hirsh MJ MD, Oster, JR MD, et al. University of Miami Division of Clinical Pharmacology therapeutic rounds: drug-induced hyperkalemia. Am J Ther. 1998; 5(2):125-132.

Ray K, Dorman S, Watson R. Severe hyperkalemia due to the concomitant use of salt substitutes and ACE inhibitors in hypertension: a potentially life threatening interaction. J Hum Hypertens. 1999;13(10):717-720.

Reif S, Klein I, Lubin F, Farbstein M, Hallak A, Gilat T. Pre-illness dietary factors in inflammatory bowel disease. Gut. 1997;40:754-760.

Sacks FM, Willett WC, Smith A, et al. Effect on blood pressure of potassium, calcium, and magnesium in women with low habitual intake. Hypertens. 1998;31(1):131-138.

Shionoiri H. Pharmacokinetic drug interactions with ACE inhibitors. Clin Pharmacokinet. 1993;25(1):20-58.

Singh RB, Singh NK, Niaz MA, Sharma JP. Effect of treatment with magnesium and potassium on mortality and reinfarction rate of patients with suspected acute myocardial infarction. Int J Clin Pharmacol Thera. 1996;34:219-225.

Stanbury RM, Graham EM. Systemic corticosteroid therapy -- side effects and their management. Br J Ophthalmol. 1998;82(6):704-708.

Suter PM. Potassium and Hypertension. Nutrition Reviews. 1998;56:151-133.

Whang R, Oei TO, Watanabe A. Frequency of hypomagnesia in hospitalized patients receiving digitalis. Arch Intern Med. 1985;145(4):655-656.

Whelton, A, Stout RL, Spilman PS, Klassen DK. Renal effects of ibuprofen, piroxicam, and sulindac in patients with asymptomatic renal failure. A prospective, randomized, crossover comparison. Ann Intern Med. 1990;112(8):568-576.

Wu G, Tian H, Han K, Xi Y, Yao Y, Ma A. Potassium magnesium supplementation for four weeks improves small distal artery compliance and reduces blood pressure in patients with essential hypertension. Clin Exp Hypertens. 2006 Jul;28(5):489-97.

Young DB, Lin H, McCabe RD. Potassium's cardiovascular protective mechanisms. Am J Physiology. 1995;268(part 2):R825-R837.

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