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Psychotherapeutic medications - phenothiazine derivatives

• Medications
• Depletions
• Editorial Note
• Supporting Research

Medications

• Chlorpromazine
  • Thorazine®
• Fluphenazine
  • Permitil® Oral
  • Prolixin Decanoate® Injection
  • Prolixin Enanthate® Injection
  • Prolixin® Injection
  • Prolixin® Oral
• Mesoridazine
  • Serentil®
• Perphenazine
  • Trilafon®
• Prochlorperazine
  • Compazine®
  • Compro™
• Thioridazine
  • Mellaril®
• Trifluoperazine
  • Stelazine®

Depletions

Coenzyme Q10

A deficiency of the antioxidant coenzyme Q10 may be associated with long-term conditions including heart disease and high blood pressure. Symptoms of deficiency include gingivitis, and weakened immune function.

Vitamin B2 (Riboflavin)

Symptoms of deficiency are sore throat, lesions of the oral cavity, including cracks at the corners of the mouth, inflammation of the skin, and other skin changes.

Editorial Note

The selected depletions information presented here identifies some of the nutrients that may be depleted by certain medications. The signs and symptoms associated with nutrient deficiency may also indicate conditions other than nutrient deficiency. If you are experiencing any of the signs or symptoms mentioned, it does not necessarily mean that you are nutrient deficient. Nutrient depletion depends upon a number of factors, including your medical history, diet, and lifestyle as well as the length of time you have been taking the medication. Please consult your healthcare provider; he or she can best assess and address your individual healthcare needs, and determine if you are at risk for nutrient depletions from these medications as well as others not listed here.

Supporting Research

Chan A, Reichmann H, Kogel A, et al. Metabolic changes in patients with mitochondrial myopathies and effects of coenzyme Q10 therapy. J Neurol . 1998;245(10):681-685.

Covington T, ed. Nonprescription Drug Therapy Guiding Patient Self-Care . St Louis, MO: Facts and Comparisons; 1999:467-545.

Folkers K, Morita M, McRee J Jr. The activities of coenzyme Q10 and vitamin B6 for immune responses. Biochem Biophys Res Commun . 1993; 28(19391):88-92.

Folkers K. Basic chemical research on coenzyme Q-10 and integrated clinical research on therapy of diseases, in Coenzyme Q, G. Lenaz, ed., John Wiley & Sons, 1985.

Kamikawa T, Kobayashi A, Yamashita T, et al. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol . 1985;56(4):247-251.

Munkholm H, Hansen HH, Rasmussen K. Coenzyme Q10 treatment in serious heart failure. Biofactors . 1999;9(2-4):285-289.

Nakamura R, Littarru GP, Folkers R, et al. Study of CoQ10-enzymes in gingiva from patients with periodontal disease and evidence for a deficiency of coenzyme Q10. Proc Natl Acad Sci USA. 1974;71(4):1456-1460.

Pinto J. et al. Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. J. Clin. Invest. 67:1, 500, 1981.

Powers HJ. Current knowledge concerning optimum nutritional status of riboflavin, niacin and pyridoxine. Proc Nutr Soc . 1999;58(2):435-440.

Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressure and insulin resistance in hypertensive patients with coronary heart disease. J Hum Hypertens. 1999;13(3):203-208.

Singh RB, Wander GS, Rastogi A, et al. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc Drugs Ther . 1998;12(4):347-353.

• Review Date: 10/1/2000
• Reviewed By: All depletions monographs have been reviewed by a team of experts including Derrick M. DeSilva, Jr., MD, Raritan Bay Medical Center, Perth Amboy, NJ; Jacqueline A. Hart, MD, Department of Internal Medicine, Newton-Wellesley Hospital, Harvard University and Senior Medical Editor, A.D.A.M., Inc., Boston, MA; John Hinze, PharmD, NMD, Woodbine, IA; Ruth Marlin, MD, Medical Director and Director of Medical Education, Preventive Medicine Research Institute, Sausalito, CA; Brian T Sanderoff, PD, BS in Pharmacy, Clinical Assistant Professor, University of Maryland School of Pharmacy; President, Your Prescription for Health, Owings Mills, MD; Leonard Wisneski, MD, FACP, George Washington University, Rockville, MD; Ira Zunin, MD, MPH, MBA, President and Chairman, Hawaii State Consortium for Integrative Medicine, Honolulu, HI.

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