Red yeast rice has been used for centuries in China as both a food and a medicinal product. It is made by fermenting a type of yeast called Monascus purpureus over red rice. In Chinese medicine, red yeast rice is used to lower cholesterol, promote blood circulation, and aid digestive problems.
Research has shown that red yeast rice contains substances that are similar to prescription statin medications. One of these substances, called monacolin K, has the same makeup as the drug lovastatin. Statins are prescribed to lower "bad" LDL cholesterol levels and help reduce the risk of heart disease.
Researchers aren't sure if the cholesterol lowering effect of red yeast rice was due to the presence of monacolin or other compounds, such as unsaturated fatty acids, isoflavones, and phytosterols, in red yeast rice. But because many red yeast rice supplements did contain monacolin, the Food and Drug Administration considered them to be drugs, not supplements, and required that manufacturers remove any red yeast rice products that contained monacolin from the market. As a result, many of the red yeast rice products now on the U.S. market may not contain monacolin. Consumers cannot distinguish between red yeast products that contain monacolin from those that don't because manufacturers make no label claims for monacolin content.
Red yeast rice has been shown in several studies to lower "bad" LDL cholesterol levels. High cholesterol levels increase the risk of heart disease. Research has shown that red yeast (Monascus purpureus) stops the action of an enzyme in the body called HMG-CoA reductase, which helps make cholesterol. Red yeast rice contains substances known as monacolins. One of these, monacolin K, has the same chemical makeup as lovastatin, a prescription drug that lowers cholesterol. Some researchers think that this substance is responsible for red yeast rice's cholesterol lowering properties. But others note that the amount of lovastatin in red yeast rice is below what you would find in the prescription drug, and think there may be other substances in red yeast rice that help lower cholesterol. More research is needed.
Several studies suggest that red yeast rice significantly reduces high cholesterol. However, most of the studies have used a formulation of red yeast rice -- Cholestin -- that is no longer available in the U.S. Although a product called Cholestin is available, it no longer contains red yeast rice. The Food and Drug Administration requires any red yeast product discovered to contain monacolin to be taken off the market. It may be hard for American consumers to know what the red yeast rice product they buy contains.
These studies support the ability of red yeast rice to lower cholesterol:
Asia and Chinese communities in North America use red yeast rice in powdered form as a food coloring for fish, alcoholic beverages, and cheese.
Red yeast rice is an ingredient in several commercially available combination supplement products that are marketed to promote heart health. Red yeast rice is also available in commercial preparations. One of the proprietary products most often studied was Cholestin, which contained monacolin. However, the Food and Drug Administration required the manufacturer to remove that product from the market. The current formulation of Cholestin does not contain red yeast rice.
People younger than 20 years should not use red yeast rice supplements.
In Traditional Chinese Medicine, the dosage of dietary or supplemental red yeast rice is as high as 6,000 - 9,000 mg per day. But the appropriate dosage for adults may vary, depending on the form of the supplement. Most studies have used standardized extract: use 600 mg (oral doses), 2 - 4 times daily.
It's not clear whether it is safe to use red yeast rice for longer than 12 weeks.
People with liver disease and those at risk for liver disease should not take red yeast rice. Red yeast rice may affect liver function in the same way prescription cholesterol lowering medications can.
The following people should not take red yeast rice: people with kidney disease, people with thyroid disorders, those at higher risk of cancer, and those with musculoskeletal disorders.
People who drink more than two alcoholic beverages a day, have a serious infection or physical disorder, or have undergone an organ transplant should also avoid using red yeast rice.
Side effects of red yeast rice are rare but can include:
Pregnant and breastfeeding women should not take red yeast rice.
People under 20 should not take red yeast rice until more research is done.
No studies have specifically looked at the safety of red yeast rice in older adults. However, elderly people who took 1,200 mg per day of red yeast rice in an 8 week study had no significant side effects.
Cholesterol-lowering medications -- Red yeast rice should not be taken with cholesterol-lowering medications unless supervised by your doctor. Red yeast rice may make the effect of these drugs stronger, increasing the risk of liver damage. If you are already taking a statin or other drug to lower cholesterol, talk to your doctor before adding red yeast rice to your regimen.
Anticoagulants (blood-thinners) -- Red yeast rice may increase the risk of bleeding.
Grapefruit juice -- If you take a statin, grapefruit and grapefruit juice can increase the amount of the drug in your blood. That can increase your risk of side effects and liver damage. Because red yeast rice may act like statins in the body, you should avoid drinking grapefruit juice or eating grapefruit while taking red yeast rice.
Coenzyme Q10 -- Statins can lower the amount of Coenzyme Q10 in the body. CoQ10 is very important in heart and muscle health and in energy production. Side effects of CoQ10 depletion include fatigue, muscle aches and pains, and muscle damage. Red yeast rice also may lower amounts of CoQ10 in the body. Ask your doctor about taking 150 - 200 mg CoQ10 at night while you are taking red yeast rice products, and for 4 weeks after you stop taking red yeast rice.
Angkak; Beni-koji; Hong qu; Hung-chu; Monascus; Red koji; Red leaven; Red rice; Xue zhi kang; Zhitai
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