If you are being treated with any of the following medications, you should not use SAMe without first talking to your health care provider.
Taking SAMe at the same time as these drugs may increase the risk of serotonin syndrome (a potentially dangerous condition caused by having too much serotonin in your body):
- Dextromethorphan (Robitussin DM, other cough syrups)
- Meperidine (Demerol)
- Pentazocine (Talwin)
- Tramadol (Ultram)
Antidepressant medications -- SAMe may interact with antidepressant medications, increasing the potential for side effects including headache, irregular or accelerated heart rate, anxiety, and restlessness. Talk to your doctor before using SAMe if you are taking any medications for depression or anxiety.
Levodopa (L-dopa) -- SAMe may reduce the effectiveness of this medication for Parkinson' s disease.
Medications for diabetes -- SAMe may reduce levels of blood sugar and may strengthen the effect of diabetes medications, which increases the risk of hypoglycemia (low blood sugar).
Drug Interactions:Antidepressant Medications
ademetionine; S-Adenosylmethionine (SAMe); SAMe
- Reviewed last on: 9/30/2007
- Steven D. Ehrlich, NMD, private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.
The information provided herein should not be used during any medical emergency or for the
diagnosis or treatment of any medical condition. A licensed medical professional should be
consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all
medical emergencies. Links to other sites are provided for information only -- they do not
constitute endorsements of those other sites. © 1997-
A.D.A.M., Inc. Any duplication or distribution of the information contained herein is
© 2011 University of Maryland Medical Center (UMMC). All rights reserved.
UMMC is a member of the University of Maryland Medical System,
22 S. Greene Street, Baltimore, MD 21201. TDD: 1-800-735-2258 or 1.866.408.6885