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Pronunciation:

(a seet a MIN oh fen & fen il to LOKS a meen)

U.S. Brand Names:

Genesec® [OTC]; Percogesic® [OTC]; Phenylgesic® [OTC]

Synonyms:

Phenyltoloxamine and Acetaminophen

Generic Available:

Yes

Use:

Relief of mild to moderate pain

Pregnancy Risk Factor:

Drug Interactions:

Acetaminophen: Substrate (minor) of CYP1A2, 2A6, 2C8/9, 2D6, 2E1, 3A4; Inhibits CYP3A4 (weak)

Ethanol/Nutrition/Herb Interactions:

Ethanol: Excessive intake of ethanol may increase the risk of acetaminophen-induced hepatotoxicity. Avoid ethanol or limit to <3 drinks/day.

Dosage:

Oral:

Analgesic: Based on acetaminophen component:

Children: 10-15 mg/kg/dose every 4-6 hours as needed; do not exceed 5 doses/24 hours

Adults: 325-650 every 4-6 hours as needed; do not exceed 4 g/day

Product labeling:

Percogesic®:

Children 6-12 years: 1 tablet every 4 hours; do not exceed 4 tablets/24 hours

Adults: 1-2 tablets every 4 hours; do not exceed 8 tablets/24 hours

Patient Education:

OTC product labeling: When used for pain, this product should not be used for more than 10 days in adults or for more than 5 days in children. When used for fever, this product should not be used for more than 3 days. May cause drowsiness. Avoid alcohol. If you consume 3 or more alcoholic drinks per day, ask your prescriber whether you should take acetaminophen, other pain relievers, or fever reducers. Acetaminophen may cause liver damage.

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

None reported

Mental Health: Effects on Psychiatric Treatment:

Barbiturates and carbamazepine may increase the hepatotoxic potential of acetaminophen

Dosage Forms:

Tablet: Acetaminophen 325 mg and phenyltoloxamine citrate 30 mg

References

Barker JD Jr, de Carle DJ, and Anuras S, "Chronic Excessive Acetaminophen Use in Liver Damage,"Ann Intern Med, 1977, 87(3):299-301.

Dionne RA, Campbell RA, Cooper SA, et al, "Suppression of Postoperative Pain by Preoperative Administration of Ibuprofen in Comparison to Placebo, Acetaminophen, and Acetaminophen Plus Codeine,"J Clin Pharmacol, 1983, 23(1):37-43.

Licht H, Seeff LB, and Zimmerman HJ, "Apparent Potentiation of Acetaminophen Hepatotoxicity by Alcohol,"Ann Intern Med, 1980, 92(4):511.

Mokhlesi B, Leikin JB, Murray P, et al, "Adult Toxicology in Critical Care: Part II: Specific Poisonings,"Chest, 2003, 123(3):897-922.

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