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Pronunciation:

(al kloe MET a sone)

U.S. Brand Names:

Aclovate®

Synonyms:

Alclometasone Dipropionate

Generic Available:

Yes: Ointment

Use:

Treatment of inflammation of corticosteroid-responsive dermatosis (low potency topical corticosteroid)

Pregnancy Risk Factor:

Contraindications:

Hypersensitivity to alclometasone or any component of the formulation; viral, fungal, or tubercular skin lesions

Warnings/Precautions:

Adverse systemic effects may occur when used on large areas of the body, denuded areas, for prolonged periods of time, with an occlusive dressing, and/or in infants or small children (not for use in children <1 year of age)

Adverse Reactions:

1% to 10%:

Dermatologic: Itching, erythema, dryness papular rash

Local: Burning, irritation

<1%: Hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, maceration of skin, skin atrophy, striae, miliaria

Overdosage/Toxicology:

Symptoms of overdose include cushingoid appearance (systemic), muscle weakness (systemic), osteoporosis (systemic) all with long-term use only. When consumed in excessive quantities for prolonged periods, systemic hypercorticism and adrenal suppression may occur; in those cases, discontinuation and withdrawal of the corticosteroid should be done judiciously.

Drug Interactions:

No data reported

Stability:

Store between 2°C and 30°C (36°F and 86°F)

Mechanism of Action:

Stimulates the synthesis of enzymes needed to decrease inflammation, suppress mitotic activity, and cause vasoconstriction

Dosage:

Topical: Apply a thin film to the affected area 2-3 times/day. Therapy should be discontinued when control is achieved; if no improvement is seen, reassessment of diagnosis may be necessary.

Administration:

For external use only; do not use on open wounds; apply sparingly to occlusive dressings; should not be used in the presence of open or weeping lesions

Patient Education:

Before applying, gently wash area to reduce risk of infection. Apply a thin film to cleansed area and rub in gently and thoroughly until medication vanishes. Avoid exposure to sunlight, severe sunburn may occur.

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

None reported

Mental Health: Effects on Psychiatric Treatment:

None reported

Dosage Forms:

Cream, as dipropionate: 0.05% (15 g, 45 g, 60 g)

Ointment, as dipropionate: 0.05% (15 g, 45 g, 60 g)

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