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Alclometasone


Pronunciation

 (al kloe MET a sone)


U.S. Brand Names

 Aclovate®


Synonyms

 Alclometasone Dipropionate


Generic Available

 Yes: Ointment


Use

 Treatment of inflammation of corticosteroid-responsive dermatosis (low potency topical corticosteroid)


Pregnancy Risk Factor

 C


Contraindications

 Hypersensitivity to alclometasone or any component of the formulation; viral, fungal, or tubercular skin lesions


Warnings/Precautions

 Adverse systemic effects may occur when used on large areas of the body, denuded areas, for prolonged periods of time, with an occlusive dressing, and/or in infants or small children (not for use in children <1 year of age)


Adverse Reactions

1% to 10%:

Dermatologic: Itching, erythema, dryness papular rash

Local: Burning, irritation

<1%: Hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, maceration of skin, skin atrophy, striae, miliaria


Overdosage/Toxicology

 Symptoms of overdose include cushingoid appearance (systemic), muscle weakness (systemic), osteoporosis (systemic) all with long-term use only. When consumed in excessive quantities for prolonged periods, systemic hypercorticism and adrenal suppression may occur; in those cases, discontinuation and withdrawal of the corticosteroid should be done judiciously.


Drug Interactions

 No data reported


Stability

 Store between 2°C and 30°C (36°F and 86°F)


Mechanism of Action

 Stimulates the synthesis of enzymes needed to decrease inflammation, suppress mitotic activity, and cause vasoconstriction


Dosage

 Topical: Apply a thin film to the affected area 2-3 times/day. Therapy should be discontinued when control is achieved; if no improvement is seen, reassessment of diagnosis may be necessary.


Administration

 For external use only; do not use on open wounds; apply sparingly to occlusive dressings; should not be used in the presence of open or weeping lesions


Patient Education

 Before applying, gently wash area to reduce risk of infection. Apply a thin film to cleansed area and rub in gently and thoroughly until medication vanishes. Avoid exposure to sunlight, severe sunburn may occur.


Dental Health: Effects on Dental Treatment

 No significant effects or complications reported


Dental Health: Vasoconstrictor/Local Anesthetic Precautions

 No information available to require special precautions


Mental Health: Effects on Mental Status

 None reported


Mental Health: Effects on Psychiatric Treatment

 None reported


Dosage Forms

Cream, as dipropionate: 0.05% (15 g, 45 g, 60 g)

Ointment, as dipropionate: 0.05% (15 g, 45 g, 60 g)


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