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Pronunciation:

(a LOO mi num hye DROKS ide, mag NEE zhum hye DROKS ide, & sye METH i kone)

U.S. Brand Names:

Alamag Plus [OTC]; Aldroxicon I [OTC]; Aldroxicon II [OTC]; Almacone® [OTC]; Almacone Double Strength® [OTC]; Maalox® [OTC]; Maalox® Max [OTC]; Mylanta® Liquid [OTC]; Mylanta® Maximum Strength Liquid [OTC]

Synonyms:

Magnesium Hydroxide, Aluminum Hydroxide, and Simethicone; Simethicone, Aluminum Hydroxide, and Magnesium Hydroxide

Generic Available:

Yes

Canadian Brand Names:

Diovol Plus®; Mylanta® Double Strength; Mylanta® Extra Strength; Mylanta® Regular Strength

Use:

Temporary relief of hyperacidity associated with gas; may also be used for indications associated with other antacids

Pregnancy Risk Factor:

Adverse Reactions:

>10%: Gastrointestinal: Chalky taste, stomach cramps, constipation, decreased bowel motility, fecal impaction, hemorrhoids

1% to 10%: Gastrointestinal: Nausea, vomiting, discoloration of feces (white speckles)

<1%: Hypophosphatemia, hypomagnesemia, dehydration or fluid restriction

Drug Interactions:

Decreased effect: Tetracyclines, digoxin, indomethacin, or iron salts, isoniazid, allopurinol, benzodiazepines, corticosteroids, penicillamine, phenothiazines, ranitidine, ketoconazole, itraconazole

Dosage:

Oral: Adults: 10-20 mL or 2-4 tablets 4-6 times/day between meals and at bedtime; may be used every hour for severe symptoms

Administration:

Administer 1-2 hours apart from oral drugs

Dietary Considerations:

Should be taken 1-3 hours after meals.

Patient Education:

Dilute dose in water or juice; chew tablets thoroughly before swallowing with water; shake well; notify physician if relief is not obtained or if signs of bleeding from GI tract occur

Dental Health: Effects on Dental Treatment:

Key adverse event(s) related to dental treatment: Chalky taste. Aluminum and magnesium ions prevent GI absorption of tetracycline by forming a large ionized chelated molecule with the tetracyclines in the stomach. Aluminum hydroxide prevents GI absorption of ketoconazole and itraconazole by increasing the pH in the GI tract. Any of these drugs should be administered at least 1 hour before aluminum hydroxide.

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

None reported

Mental Health: Effects on Psychiatric Treatment:

Constipation is common; use with low potency antipsychotics and TCAs will likely result in additive effects

Dosage Forms:

Liquid: Aluminum hydroxide 200 mg, magnesium hydroxide 200 mg, and simethicone 20 mg per 5 mL (360 mL); aluminum hydroxide 400 mg, magnesium hydroxide 400 mg, and simethicone 40 mg per 5 mL (360 mL)

Aldroxicon I: Aluminum hydroxide 200 mg, magnesium hydroxide 200 mg, and simethicone 20 mg per 5 mL (30 mL)

Aldroxicon II: Aluminum hydroxide 400 mg, magnesium hydroxide 400 mg, and simethicone 40 mg per 5 mL (30 mL)

Almacone®: Aluminum hydroxide 200 mg, magnesium hydroxide 200 mg, and simethicone 20 mg per 5 mL (360 mL)

Almacone Double Strength: Aluminum hydroxide 400 mg, magnesium hydroxide 400 mg, and simethicone 40 mg per 5 mL (360 mL)

Maalox®: Aluminum hydroxide 200 mg, magnesium hydroxide 200 mg, and simethicone 20 mg per 5 mL (360 mL, 770 mL) [lemon and mint flavors]

Maalox® Max: Aluminum hydroxide 400 mg, magnesium hydroxide 400 mg, and simethicone 40 mg per 5 mL (360 mL, 770 mL) [cherry, vanilla creme, and wild berry flavors]

Mylanta®: Aluminum hydroxide 200 mg, magnesium hydroxide 200 mg, and simethicone 20 mg per 5 mL (180 mL, 360 mL, 720 mL) [original, cherry, and mint flavors]

Mylanta® Maximum Strength: Aluminum hydroxide 400 mg, magnesium hydroxide 400 mg, and simethicone 40 mg per 5 mL (180 mL, 360 mL, 720 mL) [original, cherry, orange creme, and mint flavors]

Suspension (Alamag Plus): Aluminum hydroxide 225 mg, magnesium hydroxide 200 mg, and simethicone 25 mg per 5 mL (360 mL)

Tablet, chewable: Aluminum hydroxide 200 mg, magnesium hydroxide 200 mg, and simethicone 25 mg

Alamag Plus: Aluminum hydroxide 200 mg, magnesium hydroxide 200 mg, and simethicone 25 mg [cherry flavor]

Almacone®: Aluminum hydroxide 200 mg, magnesium hydroxide 200 mg, and simethicone 20 mg [peppermint flavor]

International Brand Names:

Diovol Plus® (CA); Mylanta™ Double Strength (CA); Mylanta™ Extra Strength (CA); Mylanta™ regular Strength (CA)

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