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Pronunciation:

(am SIN oh nide)

U.S. Brand Names:

Cyclocort®

Generic Available:

Yes

Canadian Brand Names:

Amcort®; Cyclocort®

Use:

Relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses (high potency corticosteroid)

Pregnancy Risk Factor:

Contraindications:

Hypersensitivity to amcinonide or any component of the formulation; use on the face, groin, or axilla

Warnings/Precautions:

Adverse systemic effects may occur when used on large areas of the body, denuded areas, for prolonged periods of time, with an occlusive dressing, and/or in infants or small children; occlusive dressings should not be used in presence of infection or weeping lesions

Adverse Reactions:

Frequency not defined.

Dermatologic: Acne, hypopigmentation, allergic dermatitis, maceration of the skin, skin atrophy, striae, miliaria, telangiectasia

Endocrine & metabolic: HPA suppression, Cushing's syndrome, growth retardation

Local: Burning, itching, irritation, dryness, folliculitis, hypertrichosis

Systemic: Suppression of HPA axis, Cushing's syndrome, hyperglycemia; these reactions occur more frequently with occlusive dressings

Miscellaneous: Secondary infection

Overdosage/Toxicology:

Symptoms of overdose include cushingoid appearance (systemic), muscle weakness (systemic), osteoporosis (systemic) all with long-term use only. When consumed in excessive quantities for prolonged periods, systemic hypercorticism and adrenal suppression may occur; in those cases, discontinuation and withdrawal of the corticosteroid should be done judiciously.

Drug Interactions:

No data reported

Mechanism of Action:

Stimulates the synthesis of enzymes needed to decrease inflammation, suppress mitotic activity, and cause vasoconstriction

Pharmacodynamics/Kinetics:

Absorption: Adequate through intact skin; increases with skin inflammation or occlusion

Metabolism: Hepatic

Excretion: Urine and feces

Dosage:

Topical: Adults: Apply in a thin film 2-3 times/day. Therapy should be discontinued when control is achieved; if no improvement is seen, reassessment of diagnosis may be necessary.

Patient Education:

Before applying, gently wash area to reduce risk of infection; apply a thin film to cleansed area and rub in gently and thoroughly until medication vanishes; avoid exposure to sunlight, severe sunburn may occur

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

None reported

Mental Health: Effects on Psychiatric Treatment:

None reported

Dosage Forms:

Cream: 0.1% (15 g, 30 g, 60 g) [contains benzyl alcohol]

Lotion: 0.1% (60 mL)

Cyclocort®: 0.1% (20 mL, 60 mL) [contains benzyl alcohol]

Ointment: 0.1% (30 g, 60 g) [contains benzyl alcohol]

Cyclocort®: 0.1% (15 g, 30 g, 60 g) [contains benzyl alcohol]

International Brand Names:

Amciderm® (DE, TH); Amcort® (CA); Amicla® (BE, LU); Cyclocort® (CA); Cycloderm® (BE); Visderm® (AR); Visisderm® (TH)

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