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Pronunciation:

(am oh BAR bi tal & see koe BAR bi tal)

U.S. Brand Names:

Tuinal® [DSC]

Synonyms:

Secobarbital and Amobarbital

Generic Available:

Use:

Short-term treatment of insomnia

Restrictions:

C-II

Pregnancy Risk Factor:

Lactation:

Excretion in breast milk unknown/not recommended

Contraindications:

Hypersensitivity to secobarbital, amobarbital, or any component of the formulation; CNS depression; marked liver impairment; latent porphyria; pregnancy

Warnings/Precautions:

Safety has not been established in children <6 years of age; potential for drug dependency exists; avoid alcoholic beverages; use with caution in patients with CHF, hepatic or renal impairment, hypovolemic shock

Adverse Reactions:

>10%:

Central nervous system: Dizziness, lightheadedness, drowsiness, "hangover" effect

Local: Pain at injection site

1% to 10%:

Central nervous system: Confusion, mental depression, unusual excitement, nervousness, faint feeling, headache, insomnia, nightmares

Gastrointestinal: Constipation, nausea, vomiting

<1%: Agranulocytosis, dermatitis, exfoliative, hallucinations, hypotension, megaloblastic anemia, respiratory depression, skin rash, Stevens-Johnson syndrome, thrombocytopenia, thrombophlebitis

Drug Interactions:

Amobarbital: Induces CYP2A6 (strong)

Secobarbital: Induces CYP2A6 (strong), 2C8/9 (strong)

Also see individual agents.

Pharmacodynamics/Kinetics:

See individual agents.

Dosage:

Adults: Oral: 1-2 capsules at bedtime

Patient Education:

See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. Breast-feeding is not recommended.

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Dosage Forms:

Capsule: Amobarbital 50 mg and secobarbital 50 mg

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