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Amobarbital and Secobarbital


Pronunciation

 (am oh BAR bi tal & see koe BAR bi tal)


U.S. Brand Names

 Tuinal® [DSC]


Synonyms

 Secobarbital and Amobarbital


Generic Available

 No


Use

 Short-term treatment of insomnia


Restrictions

 C-II


Pregnancy Risk Factor

 D


Lactation

 Excretion in breast milk unknown/not recommended


Contraindications

 Hypersensitivity to secobarbital, amobarbital, or any component of the formulation; CNS depression; marked liver impairment; latent porphyria; pregnancy


Warnings/Precautions

 Safety has not been established in children <6 years of age; potential for drug dependency exists; avoid alcoholic beverages; use with caution in patients with CHF, hepatic or renal impairment, hypovolemic shock


Adverse Reactions

>10%:

Central nervous system: Dizziness, lightheadedness, drowsiness, "hangover" effect

Local: Pain at injection site

1% to 10%:

Central nervous system: Confusion, mental depression, unusual excitement, nervousness, faint feeling, headache, insomnia, nightmares

Gastrointestinal: Constipation, nausea, vomiting

<1%: Agranulocytosis, dermatitis, exfoliative, hallucinations, hypotension, megaloblastic anemia, respiratory depression, skin rash, Stevens-Johnson syndrome, thrombocytopenia, thrombophlebitis


Drug Interactions

Amobarbital: Induces CYP2A6 (strong)

Secobarbital: Induces CYP2A6 (strong), 2C8/9 (strong)

Also see individual agents.


Pharmacodynamics/Kinetics

 See individual agents.


Dosage

 Adults: Oral: 1-2 capsules at bedtime


Patient Education

 See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. Breast-feeding is not recommended.


Dental Health: Effects on Dental Treatment

 No significant effects or complications reported


Dental Health: Vasoconstrictor/Local Anesthetic Precautions

 No information available to require special precautions


Dosage Forms

 Capsule: Amobarbital 50 mg and secobarbital 50 mg


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