Amoxicillin

Pronunciation

(a moks i SIL in)

U.S. Brand Names

Amoxil®; DisperMox™; Moxilin®; Trimox®

Synonyms

Amoxicillin Trihydrate; Amoxycillin; p -Hydroxyampicillin

Generic Available

Yes: Excludes tablet for oral suspension

Canadian Brand Names

Amoxil®; Apo-Amoxi®; Gen-Amoxicillin; Lin-Amox; Novamoxin®; Nu-Amoxi; PMS-Amoxicillin

Use

Treatment of otitis media, sinusitis, and infections caused by susceptible organisms involving the respiratory tract, skin, and urinary tract; prophylaxis of bacterial endocarditis in patients undergoing surgical or dental procedures; as part of a multidrug regimen for H. pylori eradication

Use - Dental

Antibiotic for standard prophylactic regimen for dental patients who are at risk for endocarditis

Use - Unlabeled/Investigational

Postexposure prophylaxis for anthrax exposure with documented susceptible organisms

Pregnancy Risk Factor

Lactation

Enters breast milk/compatible

Contraindications

Hypersensitivity to amoxicillin, penicillin, or any component of the formulation

Warnings/Precautions

In patients with renal impairment, doses and/or frequency of administration should be modified in response to the degree of renal impairment; a high percentage of patients with infectious mononucleosis have developed rash during therapy with amoxicillin; a low incidence of cross-allergy with other beta-lactams and cephalosporins exists

Adverse Reactions

Frequency not defined.

Central nervous system: Hyperactivity, agitation, anxiety, insomnia, confusion, convulsions, behavioral changes, dizziness

Dermatologic: Acute exanthematous pustulosis, erythematous maculopapular rash, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, hypersensitivity vasculitis, urticaria

Gastrointestinal: Nausea, vomiting, diarrhea, hemorrhagic colitis, pseudomembranous colitis, tooth discoloration (brown, yellow, or gray; rare)

Hematologic: Anemia, hemolytic anemia, thrombocytopenia, thrombocytopenia purpura, eosinophilia, leukopenia, agranulocytosis

Hepatic: Elevated AST (SGOT) and ALT (SGPT), cholestatic jaundice, hepatic cholestasis, acute cytolytic hepatitis

Renal: Crystalluria

Overdosage/Toxicology

Symptoms of penicillin overdose include neuromuscular hypersensitivity (eg, agitation, hallucinations, asterixis, encephalopathy, confusion, and seizures). Electrolyte imbalance may occur if the preparation contains potassium or sodium salts, especially in renal failure. Hemodialysis may be helpful to aid in removal of the drug from blood; otherwise, treatment is symptom-directed and supportive.

Drug Interactions

Allopurinol: Theoretically has an additive potential for amoxicillin rash

Aminoglycosides: May be synergistic against selected organisms

Methotrexate: Penicillins may increase the exposure to methotrexate during concurrent therapy; monitor.

Oral contraceptives: Anecdotal reports suggesting decreased contraceptive efficacy with penicillins have been refuted by more rigorous scientific and clinical data.

Probenecid, disulfiram: May increase levels of penicillins (amoxicillin)

Warfarin: Effects of warfarin may be increased

Stability

Amoxil®: Oral suspension remains stable for 14 days at room temperature or if refrigerated (refrigeration preferred); unit-dose antibiotic oral syringes are stable for 48 hours.

DisperMox™: Dissolve 1 tablet in ~10 mL water immediately before use.

Mechanism of Action

Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin binding proteins (PBPs); which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

Pharmacodynamics/Kinetics

Absorption: Oral: Rapid and nearly complete; food does not interfere

Distribution: Widely to most body fluids and bone; poor penetration into cells, eyes, and across normal meninges

Pleural fluids, lungs, and peritoneal fluid; high urine concentrations are attained; also into synovial fluid, liver, prostate, muscle, and gallbladder; penetrates into middle ear effusions, maxillary sinus secretions, tonsils, sputum, and bronchial secretions; crosses placenta; low concentrations enter breast milk

CSF:blood level ratio: Normal meninges: <1%; Inflamed meninges: 8% to 90%

Protein binding: 17% to 20%

Metabolism: Partially hepatic

Half-life elimination:

Neonates, full-term: 3.7 hours

Infants and Children: 1-2 hours

Adults: Normal renal function: 0.7-1.4 hours

Clcr<10 mL/minute: 7-21 hours

Time to peak: Capsule: 2 hours; Suspension: 1 hour

Excretion: Urine (80% as unchanged drug); lower in neonates

Dosage

Oral:

Children 3 months: 20-30 mg/kg/day divided every 12 hours

Children: >3 months and <40 kg: Dosing range: 20-50 mg/kg/day in divided doses every 8-12 hours

Ear, nose, throat, genitourinary tract, or skin/skin structure infections:

Mild to moderate: 25 mg/kg/day in divided doses every 12 hours or 20 mg/kg/day in divided doses every 8 hours

Severe: 45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours

Acute otitis media due to highly-resistant strains of S. pneumoniae: Doses as high as 80-90 mg/kg/day divided every 12 hours have been used

Lower respiratory tract infections: 45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours

Subacute bacterial endocarditis prophylaxis: 50 mg/kg 1 hour before procedure

Anthrax exposure (unlabeled use): Note: Postexposure prophylaxis only with documented susceptible organisms:

<40 kg: 15 mg/kg every 8 hours

40 kg: 500 mg every 8 hours

Adults: Dosing range: 250-500 mg every 8 hours or 500-875 mg twice daily; maximum dose: 2-3 g/day

Ear, nose, throat, genitourinary tract or skin/skin structure infections:

Mild to moderate: 500 mg every 12 hours or 250 mg every 8 hours

Severe: 875 mg every 12 hours or 500 mg every 8 hours

Lower respiratory tract infections: 875 mg every 12 hours or 500 mg every 8 hours

Endocarditis prophylaxis: 2 g 1 hour before procedure

Helicobacter pylori eradication: 1000 mg twice daily; requires combination therapy with at least one other antibiotic and an acid-suppressing agent (proton pump inhibitor or H2 blocker)

Anthrax exposure (unlabeled use): Note: Postexposure prophylaxis only with documented susceptible organisms: 500 mg every 8 hours

Dosing interval in renal impairment: The 875 mg tablet should not be used in patients with Clcr<30 mL/minute.

Clcr 10-30 mL/minute: 250-500 mg every 12 hours

Clcr<10 mL/minute: 250-500 mg every 24 hours

Dialysis: Moderately dialyzable (20% to 50%) by hemo- or peritoneal dialysis; approximately 50 mg of amoxicillin per liter of filtrate is removed by continuous arteriovenous or venovenous hemofiltration; dose as per Clcr<10 mL/minute guidelines

Administration

Administer around-the-clock to promote less variation in peak and trough serum levels. The appropriate amount of suspension may be mixed with formula, milk, fruit juice, water, ginger ale or cold drinks; administer dose immediately after mixing.

DisperMox™: Dissolve 1 tablet in ~10 mL of water immediately before administration. Rinse container with additional water and drink entire contents to ensure that complete dose is taken. Do not chew or swallow tablet whole.

Monitoring Parameters

With prolonged therapy, monitor renal, hepatic, and hematologic function periodically; assess patient at beginning and throughout therapy for infection; monitor for signs of anaphylaxis during first dose

Test Interactions

May interfere with urinary glucose tests using cupric sulfate (Benedict's solution, Clinitest®); may inactivate aminoglycosides in vitro

Dietary Considerations

May be taken with food. Amoxil® chewable contains phenylalanine 1.82 mg per 200 mg tablet, phenylalanine 3.64 mg per 400 mg tablet. DisperMox™ contains phenylalanine 5.6 mg in each 200 mg and 400 mg tablet.

Patient Education

Inform prescriber of all prescriptions, OTC medications, or herbal products you are taking, and any allergies you have. Do not take any new medication during therapy unless approved by prescriber. Take entire prescription, even if you are feeling better. Take at equal intervals around-the-clock. May be taken with milk, juice, or food. If you have diabetes, drug may cause false test results with Clinitest® urine glucose monitoring; use of another type of glucose monitoring is preferable. May cause nausea or vomiting (small, frequent meals, frequent mouth care, sucking lozenges, or chewing gum may help). Report rash; unusual diarrhea; vaginal itching, burning, or pain; unresolved vomiting or constipation; fever or chills; abdominal pain; jaundice; unusual bruising or bleeding; or if condition being treated worsens or does not improve by the time prescription is completed.

Cardiovascular Considerations

For the prevention of bacterial endocarditis, amoxicillin 2 g orally can be given 1 hour before, in the absence of a contraindication, for a dental, oral, respiratory tract, or esophageal procedure.

Dental Health: Effects on Dental Treatment

Prolonged use of penicillins may lead to development of oral candidiasis.

Dental Health: Vasoconstrictor/Local Anesthetic Precautions

No information available to require special precautions

Mental Health: Effects on Mental Status

Rarely large doses may produce confusion, hallucinations, and depression; penicillins have been reported to cause apprehension, illusions, agitation, insomnia, depersonalization, and encephalopathy

Mental Health: Effects on Psychiatric Treatment

Disulfiram may increase amoxicillin levels

Dosage Forms

[DSC] = Discontinued product

Capsule, as trihydrate: 250 mg, 500 mg

Amoxil®: 250 mg [DSC], 500 mg

Moxilin®, Trimox®: 250 mg, 500 mg

Powder for oral suspension, as trihydrate: 125 mg/5 mL (80 mL, 100 mL, 150 mL); 200 mg/5 mL (50 mL, 75 mL, 100 mL); 250 mg/5 mL (80 mL, 100 mL, 150 mL); 400 mg/5 mL (50 mL, 75 mL, 100 mL)

Amoxil®: 125 mg/5 mL (150 mL) [contains sodium benzoate; strawberry flavor] [DSC]; 200 mg/5 mL (5 mL, 50 mL, 75 mL, 100 mL) [contains sodium benzoate; bubble gum flavor]; 250 mg/5 mL (100 mL, 150 mL) [contains sodium benzoate; bubble gum flavor]; 400 mg/5 mL (5 mL, 50 mL, 75 mL, 100 mL) [contains sodium benzoate; bubble gum flavor]

Moxilin®: 250 mg/5 mL (100 mL, 150 mL)

Trimox®: 125 mg/5 mL (80 mL, 100 mL, 150 mL); 250 mg/5 mL (80 mL, 100 mL, 150 mL) [contains sodium benzoate; raspberry-strawberry flavor]

Powder for oral suspension, as trihydrate [drops] (Amoxil®): 50 mg/mL (15 mL [DSC], 30 mL) [bubble gum flavor]

Tablet, as trihydrate [film coated] (Amoxil®): 500 mg, 875 mg

Tablet, chewable, as trihydrate: 125 mg, 200 mg, 250 mg, 400 mg

Amoxil®: 200 mg [contains phenylalanine 1.82 mg/tablet; cherry banana peppermint flavor]; 400 mg [contains phenylalanine 3.64 mg/tablet; cherry banana peppermint flavor]

Tablet, for oral suspension, as trihydrate (DisperMox™): 200 mg [contains phenylalanine 5.6 mg; strawberry flavor]; 400 mg [contains phenylalanine 5.6 mg; strawberry flavor]; 600 mg [contains phenylalanine 11.23 mg; strawberry flavor]

References

Boguniewicz M and Leung DY, "Hypersensitivity Reactions to Antibiotics Commonly Used in Children," Pediatr Infect Dis J , 1995, 14(3):221-31.

Canafax, DM, Yuan Z, Chonmaitree T, et al, "Amoxicillin Middle Ear Fluid Penetration and Pharmacokinetics in Children with Acute Otitis Media," Pediatr Infect Dis J , 1998, 17(2):149-56.

Dajani AS, Taubert KA, Wilson WW, et al, "Prevention of Bacterial Endocarditis. Recommendations by the American Heart Association," JAMA 1997, 277(22):1794-801.

Donowitz GR and Mandell GL, "Beta-Lactam Antibiotics," N Engl J Med , 1988, 318(7):419-26 and 318(8):490-500.

Dougall HT, et al, "The Effect of Amoxicillin on Salivary Nitrite Concentrations: An Important Mechanism of Adverse Reactions?" Br J Clin Pharmacol , 1995, 39(4):460-2.

Hautekeete ML, Brenard R, Horsmans Y, et al, "Liver Injury Related to Amoxycillin-Clavulanic Acid: Interlobular Bile-Duct Lesions and Extrahepatic Manifestations," J Hepatol , 1995, 22(1):71-7.

Hill S, Yeates M, Pathy J, et al, "A Controlled Trial of Norfloxacin and Amoxicillin in the Treatment of Uncomplicated Urinary Tract Infection in the Elderly," J Antimicrob Chemother , 1985, 15(4):505-6.

Jones KH and Hill SA, "The Toxicology, Absorption and Pharmacokinetics of Amoxicillin," Adv Clin Pharmacol , 1974, 7:20.

Oe PL, et al, "Pharmacokinetics of the New Penicillins, Amoxicillin and Flucloxacillin in Patients With Terminal Renal Failure Undergoing Hemodialysis," Chemotherapy , 1973, 19:279.

Parry MF, "The Penicillins," Med Clin North Am , 1987, 71(6):1093-112.

Prignet JM, Galzin M, Duval JL, et al, "Amoxicillin-Induced Esophageal Ulcer With Intractable Hiccups as the Presenting Manifestation," Semaine des Hopitaux , 1995, 71:186-7.

U.S. Food and Drug Administration, Center for Drug Evaluation and Research, "Commentary on Non-Labeled Dosing of Oral Amoxicillin in Adults and Pediatrics for Post-Exposure Inhalational Anthrax," December 10, 2001. Available at: http://www.fda.gov/cder/drugprepare/amox-anthrax.htm. Accessed January 11, 2002.

Westphal JF, Jehl F, Brogard JM, et al,"Amoxicillin Intestinal Absorption Reduction by Amiloride: Possible Role of the Na⁺ -H⁺ Exchanger," Clin Pharmacol Ther , 1995, 57(3):257-64.

Wright AJ, "The Penicillins," Mayo Clin Proc , 1999, 74(3):290-307.

Wynn RL, "Amoxicillin Update," Gen Dent , 1991, 39(5):322,4,6.

International Brand Names

Abdimox® (ID); Abiolex® (CL); Abiotyl® (AR); Acimox® (MX); Acromox® (EC); Acroxil® (MX); Acticillin® (TH); Actimoxi® (ES); Acucil® (ZA); Adbiotin (CO); Adco-Amoxycillin® (ZA); Agerpen® (ES); Agram® (FR); A-Lennon Amoxycillin® (ZA); Alfamox® (IT); Alfoxil Enjektabl® [inj.] (TR); Alfoxil® (TR); Almacin® (HR, YU); Almodan® (GB); Alphamox® (AU); Amacin® (TH); Amagesan® (DE); AMC-Puren® (DE); Amimox® (SE); Amitron® (ES); Amixen® (AR); Amix® (GB); Amobay® (MX); Amobiotic® (CL, ID); Amocilline® (AT); Amocillin® (ZA); Amoclen® (CZ, RO); Amodex® (FR); Amodex® [inj.] (FR); Amoflux® (IT); Amohexal® (AU); Amoksicilin® (HR, SI, YU); Amoksilin® (TR); Amoksina® (TR); Amolin® (JP); Amopen® (BG, RO); Amoram® (GB); Amorion® (FI); Amosine® (ID); Amosol® (IT); Amotaks® (PL); Amotid® (RU); Amoval 1G® (CL); Amoval® (CL, EC); Amoxal® (CO); Amoxapen® (CY, HK, SG); Amoxaren® (ES); Amoxa® (SG, TH); Amox® (BD, IT, RO); Amoxcillin® (TH); Amox-G® (AR); Amoxi 1A Pharma® (DE); Amoxi AbZ® (DE); Amoxibacter® (ES); amoxi-basan® (CH); Amoxi® (BD, BE, IL, LU); Amoxibeta® (DE); Amoxibiot® (AR); Amoxibron® (BR); Amoxicap® (SG); Amoxicher® (EC); Amoxicid® (RO); Amoxicilina Ariston® (EC); Amoxicilina Belmac® (ES); Amoxicilina Benox® (ES); Amoxicilina Bohm® (ES); Amoxicilina® (BR, CL, CO, EC, RO); Amoxicilina CBA® (AR); Amoxicilina Cinfa® (ES); Amoxicilina Davur® (ES); Amoxicilina Drawer® (AR); Amoxicilina Edigen® (ES); Amoxicilina Esteve® (ES); Amoxicilina Fada® (AR); Amoxicilina Farmygel® (ES); Amoxicilina Fecofar® (AR); Amoxicilina Forte® (RO); Amoxicilina Geminis® (ES); Amoxicilina Genfar® (EC); Amoxicilina Juventus® (ES); Amoxicilina Lacefa® (AR); Amoxicilina L.CH.® (CL); Amoxicilina Llorente® (ES); Amoxicilina Medipharma® (AR); Amoxicilina MK® (CO, CR, DO, GT, HN, PA, SV); Amoxicilina Mundogen® (ES); Amoxicilina Normon® (ES); Amoxicilina Ratiopharm® (ES); Amoxicilina Richet® (AR); Amoxicilina Sabater® (ES); Amoxicilina SmithKline® (ES); Amoxicilina Suamoxil® (ES); Amoxicilina Ur® (ES); AmoxicilinaVannier® (AR); Amoxicillina Bioprogress® (IT); Amoxicillin acis® (DE); Amoxicillina Copernico® (IT); Amoxicillina DOC® (IT); Amoxicillina EG® (IT); Amoxicillina Francia® (IT); Amoxicillina GNR® (IT); Amoxicillina Hexan® (IT); Amoxicillina K24® (IT); Amoxicillin AL® (DE); Amoxicillina Merck® (IT); Amoxicillina OFF® (IT); Amoxicillina Pliva® (IT); Amoxicillina-ratiopharm® (IT); Amoxicillina Union Health® (IT); Amoxicillin AZU® (DE); Amoxicillin-B® (HU); Amoxicillin-Biochemie® (CH); Amoxicillin® (CZ, GB, ID, NO, RU); Amoxicillin "Dyna"® (AT); Amoxicilline BC® (BE); Amoxicilline EG® (BE); Amoxicilline-Eurogenerics® (LU); Amoxicilline® (PL); Amoxicilline ratiopharm® (BE); Amoxicillin Generics® (FI); Amoxicillin HelvePharm® (CH); Amoxicillin Heumann® (DE); Amoxicillin Hexal® (ZA); Amoxicillin NM® (DK); Amoxicillin PB® (DE); Amoxicillin-ratiopharm® (AT, DE, LU, RU); Amoxicillin RX® (TH); Amoxicillin Sandoz® (CH); Amoxicillin Scand Pharm® (SE); Amoxicillin Schoeller Chemie® (AT); Amoxicillin Sodium® (GB); Amoxicillin Stada® (DE); Amoxicina Oriental® (AR); Amoxicler® (AR); Amoxicon® (BD); Amoxidal® (AR, CO); Amoxidel® (ES); Amoxid® (HK); Amoxi-Diolan® (DE); Amoxidoc® (DE); Amoxi EWE® (AR); Amoxifar® (BR); Amoxifarm® (RO); Amoxifur® (MX); Amoxiga® (CO); Amoxigea® (DK); Amoxi GNO® (AR); Amoxi Gobens® [caps./liqu.oral] (DO, ES, GT, SV); Amoxi Gobens® [inj.] (ES); Amoxigrand® (AR); Amoxigran® (SG); Amoxi-Hefa® (DE); Amoxihexal® (AT, CZ); Amoxi-Hexal® (DE); Amoxihexal® (LU); Amoxi HP® (DE); Amoxi-infant® (DE); Amoxilan® (AT); Amoxil® (AU, BR, CA, EC, GB, HK, HR, ID, IE, IN, MX, NZ, PL, SG, SI, ZA); Amoxil-Bencard® (TH); Amoxi-Lich® (DE); Amoxil® [inj.] (AU, GB, ID, RO, SI, ZA); Amoxillat® (DE); Amoxillin® (ID, IT, KW, NO, SI); Amoxi L.U.T.® (DE); Amoximedical® (ES); Amoxi-Mepha® (CH); Amoximerck® (DE); Amoximex® (CH); Amoxina® (BR, IT); Amoxin® (BD, FI); Amoxinovag® (MX); Amoxi-Ped® (BR); Amoxipen® (BE); Amoxipenil® (AR); Amoxiphar® (BE); Amoxipoten® (AR); Amoxi-Puren® (DE); Amoxi-Sandoz® (DE); Amoxisol® (MX); Amoxistad® (AT); Amoxi-Tablinen® (DE); Amoxitenk® (AR); Amoxivan® (IN); Amoxivet® (MX); amoxi von ct® (DE); Amoxi-Wolff® (DE); Amoxol® (AR); Amoxon® (BD); Amoxport® (CR, DO, GT, HN, PA, SV); Amoxsan® (ID); Amoxycaps® (BE); Amoxycillin® (PL, RO); Amoxydar® (HK, JO, KW, LB, MT, MY, RO); Amoxy-Diolan® (CY, KW, LB, RO, SY); Amoxyfizz® (ZA); Amoxylin® (TH); Amoxy M H® (TH); Amoxypen® (BE, DE, LU); Amoxy P® (TH); Amoxy® (TH); Amplamox® (BR, PT); Ampliron® (MX); Antiotic® (CH); Apamox® (ES); Apo-Amoxi® (CA, CZ, NZ, PL, SG); Arcamox® (ID); Ardine® (AR, ES, MX); Aristomox® (BD); Aroxin® (HK, SG); Asiamox® (TH); Atenac® (DO); Atrival® (AR); Avlomox® (BD); Azillin® (CH); Bactamox® (BD, CR, DO, GT, HN, PA, SV); Bactimed® (BE); Bactox® (FR); Bactox® [inj.] (FR); Bellacid® (ID); Benzoral® (BR); Betamox® (ZA); Bgramin® (AU); Bimox® (CO); Bintamox® (ID); Bioksil® (TR); Biomoxil® (IN); Biomox® (IN); Biotamoxal® (AR); Bioxilina® (AR); Bioxilina® [inj.] (AR); Bioxyllin® (ID); Bitoxil® (BD); Bolchipen® (ES); Borbalan® (ES); Bradimox® (IT); Bristamox® (EC, FR); Britamox® (ES); Brondix® (ES); Calmoxyl® (ES); Cefamoxil® (HN); Chem mart Amoxycillin® (AU); Chemoxilin® (BD); Chenamox® (EC); Cilamox® (AU); Cipamox® (PT); Clamox® (FI); Clamoxyl® (AT, BE, CH, DE, ES, FR, NL, PT); Clamoxyl® [inj.] (BE, CH, ES, FR, NL); Clonamox® (HU, IE); C-Mox® (ZA); Co Amoxin® (ES); Coamox® (TH); Corsamox® (ID); Curamox Vet® (NO); Damoxy® (IN); Danoxilin® (ID); Darzitil® (AR); DBL Amoxycillin® (AU); Demoksil® (TR); Dexymox® (ID); Dispamox® (RO); Dobriciclin® (ES); Docamoxici® (BE); Dodemox® (IT); Dopen® (BD); Drupox® (IT); Dunox® (AR); Duomox® (BG, CZ, HU, PL, RO); Ecumox (EC); Edoxil® (ES); Efpenix® (JP); E.Mox® (EG, JO, KW, LB); E-Mox® (RO); Ephamox® (RO); Epicocillin® (EG, JO, KW, LB); Eramox® (AT); Escamox® (CH); espa-moxin® (DE); Ethimox® (ID); Eupen® (DO, ES, GT, HN, SV); Farconcil® (RO); Farmoxil® (BR); Farmoxyl® [syrup] (ID); Fimoxyl® (BD); Fisamox for Injection® (AU); Flemoxin® (BE, CH, IN, LU, NL, RO); Flémoxine® (FR); Flemoxin® [inj.] (NL); Flemoxin Solutab® (DK, FI); Flemoxin solutab® (LU); Flemoxin Solutab® (NO, PT, RU); Flemoxon® [tabs] (AR, BR, CO, MX); Flubiotic NF® (ES); Flui-Amoxicillin® (DE); Fullcilina® (AR); Galenamox® (GB, IE); G-Amoxycillin® (BD); Gen-Amoxicillin (CA); Genimox® (IT); GenRX Amoxycillin® (AU); Geramox® (IE); Gimalxina® (MX); Goxallin® (ID); Gramidil® (FR, LU); Grinsil® (AR); Grunamox® (EC, LU, PL, RU); Grunicina® (MX); Healthsense Amoxycillin® (AU); HeliClear® (GB); Helicocin® (RO); Hiconcil® (BD, BE, BR, FR, IL, LU, PL, RU, SI); Hidramox® (MX); Hipen® (IN); Hosboral® (ES); H-Pambiotico® (CO); Humamoxin® (HU); Hydramox® (IT); Ibiamox® [inj.] (IT, NZ, TH); Ikamoxyl® (ID); Imacillin® (DK, NO, SE); Imadrax® (DK); Imaxilin® (CO); Imox® (IN); Infectomox® (CZ, DE); Intermoxil® (ID); Ipcamox® (ZA); Isimoxin® (IT); Izoltil® (RO); Jamoxil® (BD); Julphamox® (EC, RO); Jutamox® (DE); Kalmoxillin® (ID); Kamoxin® (TH); Kemosilin® (ID); Kimoxil® (ID); Lapimox® (ID); Largopen® [inj.] (TR); Largopen® (TR); Larocilin® (AR); Leomycillin® (ID); Libramox® (EC); Lin-Amox (CA); Loxyn® (IN); Maconcil® (ID); Manmox® (TH); Maxcil® (ZA); Mediamox® (ES); Medimox® (ID); Medocyl® (ID); Megamox® (SI); Meixil® (TH); Merck-Amoxicilline® (BE); Mestamox® (ID); Milamox® (TH); Moksilin® (TR); Monamox® (BD); Mopen® (IT); Morgenxil® (ES); Moxacil® (BD); Moxacin® [caps./liqu.oral] (AU); Moxacin® [inj.] (AU); Moxadent® (PT); Moxaline® (BE, LU); Moxan® (ZA); Moxapen® (TH); Moxcil TP® (TH); Moxcin® (TH); Moxilcap® (TH); Moxilen® (CY, JO, RO, SG); Moxilin® (BD, TH); Moximed® (TH); Mox® (IN); Moxin® (BD); Moxipan® (TH); Moxipen® (SG); Moxiplus® (BR); Moxiren® (IT); Moxitop® (BE); Moxitral® (AR); Moxlin® [caps] (ID, MX, NZ); Moxtid® (ID); Moxylin® (EC); Moxypen® (IL, RO, ZA); Moxyvit® (IL, RO); Neamoxyl® (CH); Neo-Ampiplus® (IT); Neogram® (CO); Neotetranase® (IT); Nobactam® (AR); Novabritine® (BE, LU); Novabritine® [inj.] (BE, LU); Novamox® (CL, IN, PL); Novamoxin® (CA, RO); Novocilin® (BR); Novoxil® (BR); Nu-Amoxi (CA); Nuclav® (IN); Nufamox® (ID); Odontocilina® (EC); Opimox® (ID); Optium® (AR); Oralmox® (IT); Oraminax® (PT); Oramox® (IE); Ospamox® (AT, CR, CY, CZ, DE, DO, GT, HU, ID, JO, KW, LB, NZ, PA, PL, PT, RO, RU, SG, SV); Oximar® (AR); Pamocil® (IT); Pasetocin® (JP); Pehamoxil® (ID); Penamox® [inj.] (MX); Penamox® (JO, KW, MX, NZ, PT, RO, SY); Penifarma® (CO); Penmox® (ID); Pentamox® (BD); Penvicilin® (BR); Phamoxi® (DE); Pinamox® (IE); PMS-Amoxicillin (CA); Polymox® (MX); Pondnoxcill® (TH); Primoxil® (ID); Probenil® (BR); Promoxil® (ZA); Q-Mox® (BD); Rancil® (TH); Ranmoxy® (ZA); Ranoxyl® (RU); Raudopen® (ES); Reloxyl® (ES); Remamox® (BD); Remisan® (ES); Remoxil® (BD, TR); Remoxil® [inj.] (TR); Respicilin® (BR); Rimoxallin® (GB); Robamox® (ID); Rolab-Amoxycillin® (ZA); Ronemox® (IN); Rottamoxil® (RO); Salvapen® (ES); Samox® (TH); Sapox® (BD); Scannoxyl® (ID); Seisapa® (AR); Servamox® (CO, MX, TH); Servimox® (BD); Sia-Mox® (TH); Sigamopen® (DE); Silamox® (ID); Sil-a-mox® (TH); Simoxil® (IT); Simplamox® (IT); Sinacilin® (YU); Sinamox® (BD); Sintopen® (IT); SK-Mox® (BD); S M Amox® (TH); Solciclina® (MX); Solpenox® (ID); Spectramox® (ZA); Spectroxyl® (CH); Sumox® (DO); Superpeni® (ES); Supramox® (AT, CH, ID); Symoxyl® (IN); Terry White Chemists Amoxycillin® (AU); Tiwimox® (ID); Tolodina® (ES); Topcillin® (ID); Topramoxin Süsp.® (TR); Topramoxin Tablet® (TR); Triamox® (CO); Trifamox® (AR); Trimosin® (TR); T.V.Mox® (TH); Tycil® (BD); Tymox® (BD); Ultramox® (BD, BG, JO, KW, LB, MA, MY, SY); Uniao Amoxicilina® (BR); Unimox® (CL, SG, TH); Velamox® (BR, IT); Velamox® [inj.] (IT); Vibramox® (ID); Widecillin® (ID, JP); Xalyn-Or® (MX); Xiltrop® (ID); Zimox® (IT); Zoxil® (ZA)

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