U.S. Brand Names:

Tenoretic®

Synonyms:

Chlorthalidone and Atenolol

Generic Available:

Yes

Canadian Brand Names:

Tenoretic®

Use:

Treatment of hypertension with a cardioselective beta-blocker and a diuretic

Pregnancy Risk Factor:

D

Lactation:

Excretion in breast milk unknown

Adverse Reactions:

See individual agents.

Drug Interactions:

See individual agents.

Pharmacodynamics/Kinetics:

See individual agents.

Dosage:

Adults: Oral: Initial (based on atenolol component): 50 mg once daily, then individualize dose until optimal dose is achieved

Dietary Considerations:

Should be taken on empty stomach.

Patient Education:

See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. Consult prescriber if breast-feeding.

Nursing Implications:

May contain povidone as inactive ingredient

Cardiovascular Considerations:

See individual components.

Dental Health: Effects on Dental Treatment:

Atenolol is a cardioselective beta-blocker. Local anesthetic with vasoconstrictor can be safely used in patients medicated with atenolol. Nonselective beta-blockers (ie, propranolol, nadolol) enhance the pressor response to epinephrine, resulting in hypertension and bradycardia; this has not been reported for atenolol. Many nonsteroidal anti-inflammatory drugs, such as ibuprofen and indomethacin, can reduce the hypotensive effect of beta-blockers after 3 or more weeks of therapy with the NSAID. Short-term NSAID use (ie, 3 days) requires no special precautions in patients taking beta-blockers.

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

May cause fatigue, insomnia, and confusion which can clinically look like depression

Mental Health: Effects on Psychiatric Treatment:

Concurrent use with other psychotropics may produce an additive hypotensive response (especially low potency antipsychotics and TCAs)

Dosage Forms:

Tablet:

50: Atenolol 50 mg and chlorthalidone 25 mg

100: Atenolol 100 mg and chlorthalidone 25 mg

International Brand Names:

Tenoretic® (CA)