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Carisoprodol and Aspirin


Pronunciation

 (kar eye soe PROE dole & AS pir in)


U.S. Brand Names

 Soma® Compound


Synonyms

 Aspirin and Carisoprodol


Generic Available

 Yes


Use

 Skeletal muscle relaxant


Use - Dental

 Treatment of muscle spasms and pain associated with acute temporomandibular joint pain


Pregnancy Risk Factor

 C/D (full-dose aspirin in 3rd trimester)


Lactation

 Enters breast milk/contraindicated


Drug Interactions

Carisoprodol: Substrate of CYP2C19 (major)

Aspirin: Substrate of CYP2C8/9 (minor)

Also see individual agents.


Ethanol/Nutrition/Herb Interactions

 Ethanol: Avoid ethanol (may increase CNS depression).


Pharmacodynamics/Kinetics

 See individual agents.


Dosage

 Oral: Adults: 1-2 tablets 4 times/day


Patient Education

 See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. Do not breast-feed.


Nursing Implications

 Raise bed rails; institute safety measures; assist with ambulation


Dental Health: Effects on Dental Treatment

 Key adverse event(s) related to dental treatment: Elderly are a high-risk population for adverse effects from nonsteroidal anti-inflammatory agents. As many as 60% of elderly patients with GI complications from NSAIDs can develop peptic ulceration and/or hemorrhage asymptomatically. Concomitant disease and drug use contribute to the risk of GI adverse effects. Use lowest effective dose for shortest period possible. Consider renal function decline with age.


Dental Health: Vasoconstrictor/Local Anesthetic Precautions

 No information available to require special precautions


Mental Health: Effects on Mental Status

 Drowsiness is common; may produce depression or paradoxical CNS stimulation


Mental Health: Effects on Psychiatric Treatment

 Rarely may cause leukopenia or aplastic anemia; use caution with clozapine and carbamazepine; concurrent use with psychotropics may produce additive sedation


Dosage Forms

 Tablet: Carisoprodol 200 mg and aspirin 325 mg


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