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Pronunciation:

(kar eye soe PROE dole, AS pir in, and KOE deen)

U.S. Brand Names:

Soma® Compound w/Codeine

Synonyms:

Aspirin, Carisoprodol, and Codeine; Codeine, Aspirin, and Carisoprodol

Generic Available:

Yes

Use:

Skeletal muscle relaxant

Use - Dental:

Treatment of muscle spasms and pain associated with acute temporomandibular joint pain

Restrictions:

C-III

Pregnancy Risk Factor:

C/D (full-dose aspirin in 3rd trimester)

Lactation:

Enters breast milk/contraindicated

Drug Interactions:

Carisoprodol: Substrate of CYP2C19 (major)

Aspirin: Substrate of CYP2C8/9 (minor)

Also see individual agents.

Ethanol/Nutrition/Herb Interactions:

Ethanol: Avoid ethanol (may increase CNS depression).

Pharmacodynamics/Kinetics:

See individual agents.

Dosage:

Oral: Adults: 1 or 2 tablets 4 times/day

Patient Education:

See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. Do not breast-feed.

Nursing Implications:

Raise bed rails; institute safety measures; assist with ambulation

Dental Health: Effects on Dental Treatment:

Key adverse event(s) related to dental treatment: Elderly are a high-risk population for adverse effects from nonsteroidal anti-inflammatory agents. As many as 60% of elderly patients with GI complications from NSAIDs can develop peptic ulceration and/or hemorrhage asymptomatically. Concomitant disease and drug use contribute to the risk of GI adverse effects. Use lowest effective dose for shortest period possible. Consider renal function decline with age.

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

Drowsiness is common; may produce depression or paradoxical CNS stimulation

Mental Health: Effects on Psychiatric Treatment:

Rarely may cause leukopenia or aplastic anemia; use caution with clozapine and carbamazepine; concurrent use with psychotropics may produce additive sedation

Dosage Forms:

Tablet: Carisoprodol 200 mg, aspirin 325 mg, and codeine phosphate 16 mg

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