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Chlorpheniramine and Acetaminophen


Pronunciation

 (klor fen IR a meen & a seet a MIN oh fen)


U.S. Brand Names

 Coricidin HBP® Cold and Flu [OTC]


Synonyms

 Acetaminophen and Chlorpheniramine


Generic Available

 No


Use

 Symptomatic relief of congestion, headache, aches and pains of colds and flu


Drug Interactions

Acetaminophen: Substrate (minor) of CYP1A2, 2A6, 2C8/9, 2D6, 2E1, 3A4; Inhibits CYP3A4 (weak)

Chlorpheniramine: Substrate of CYP2D6 (minor), 3A4 (major); Inhibits CYP2D6 (weak)

Also see individual agents.


Ethanol/Nutrition/Herb Interactions

 Ethanol: Avoid ethanol (may increase CNS depression).


Pharmacodynamics/Kinetics

 See individual agents.


Dosage

 Adults: Oral: 2 tablets every 4 hours


Dental Health: Effects on Dental Treatment

 Key adverse event(s) related to dental treatment: Chronic use of antihistamines will inhibit salivary flow, particularly in elderly patients; this may contribute to periodontal disease and oral discomfort.


Dental Health: Vasoconstrictor/Local Anesthetic Precautions

 No information available to require special precautions


Mental Health: Effects on Mental Status

 Drowsiness is common; may cause excitability, nervousness, fatigue, or depression


Mental Health: Effects on Psychiatric Treatment

 Dry mouth and sedation may be exacerbated by concurrent psychotropic use


Dosage Forms

 Tablet: Chlorpheniramine maleate 2 mg and acetaminophen 325 mg


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