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Pronunciation:

(kole e kal SI fer ole)

U.S. Brand Names:

Delta-D®

Synonyms:

Generic Available:

Yes

Canadian Brand Names:

D-Vi-Sol®

Use:

Dietary supplement, treatment of vitamin D deficiency, or prophylaxis of deficiency

Pregnancy Risk Factor:

Contraindications:

Hypercalcemia; hypersensitivity to cholecalciferol or any component of the formulation; malabsorption syndrome; evidence of vitamin D toxicity

Adverse Reactions:

Frequency not defined.

Cardiovascular: Arrhythmia, hyper-/hypotension, cardiac arrhythmia

Central nervous system: Irritability, headache, somnolence, overt psychosis (rare)

Dermatologic: Pruritus

Endocrine & metabolic: Polydipsia

Gastrointestinal: Nausea, vomiting, anorexia, pancreatitis, metallic taste, dry mouth, constipation, weight loss

Genitourinary: Albuminuria, polyuria

Hepatic: Increased liver function test

Neuromuscular & skeletal: Bone pain, myalgia, weakness, muscle pain

Ocular: Conjunctivitis, photophobia

Renal: Azotemia, nephrocalcinosis

Drug Interactions:

Inhibits CYP2C8/9 (weak), 2C19 (weak), 2D6 (weak)

Thiazide diuretics, cholestyramine, colestipol, corticosteroids, mineral oil, phenytoin, barbiturates, digitalis glycosides, antacids (magnesium)

Dosage:

Adults: Oral: 400-1000 units/day

Patient Education:

Do not take more than the recommended amount. While taking this medication, your physician may want you to follow a special diet or take a calcium supplement. Follow this diet closely. Avoid taking magnesium supplements or magnesium containing antacids. Early symptoms of hypercalcemia include weakness, fatigue, somnolence, headache, anorexia, dry mouth, metallic taste, nausea, vomiting, cramps, diarrhea, muscle pain, bone pain, and irritability.

Nursing Implications:

Do not administer more than the recommended amount. While taking this medication, your physician may want you to follow a special diet or take a calcium supplement. Follow this diet closely. Avoid taking magnesium supplements or magnesium containing antacids. Early symptoms of hypercalcemia include weakness, fatigue, somnolence, headache, anorexia, dry mouth, metallic taste, nausea, vomiting, cramps, diarrhea, muscle pain, bone pain, and irritability.

Dental Health: Effects on Dental Treatment:

Key adverse event(s) related to dental treatment: Metallic taste and xerostomia (normal salivary flow resumes upon discontinuation).

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

May cause irritability; rare reports of psychosis

Mental Health: Effects on Psychiatric Treatment:

None reported

Dosage Forms:

Tablet: 1000 int. units

Delta-D®: 400 int. units

International Brand Names:

Arachitol® (IN); Calcirol® (IN); Colecalciferol® (CL); D!3-Vicotrat® (DE); D-Cure® (BE, LU); Dedrei® (DE); Deetipat® (FI); Dekristol® (DE); Devaron® (NL); Devit-3® (TR); D-Vi-Sol® (CA); Fluor-Vigantoletten® (RO); Laevovit D!3® (AT, HU); Neo Dohyfral D3® [inj.] (NL); Oleovit D!3® (AT); Ospur D!3® (DE); Ostelavit® (PL); Plivit D3® (HR, SI); Raqui-D3® (EC); Raquiferol® (EC); Tridelta® (IT); Uvédose® (FR, LU); Vi-De 3® (AT, CH); Vigantol® (CZ, DE, HU, LU, PL, RO, RU, YU); Vigantoletten® (DE, HR, LU, PL); Vitamina D3 Berenguer® (ES); Vitamina D3® (RO); Vitamin D!3 Bioextra® (HU); Vitamin D!3 Fresenius® (HU); Vitamin D3 Hevert® (DE); Vitamin D!3® (RU); Vitamin D!3 Streuli® (CH); Vitamine D3 BON® (FR); Vitamine D FNA® (NL); Vitaminum D3® (PL); Vitamon D3® (BE); Zymad® (FR)

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