Pronunciation:

(sye kloe PEER oks)

U.S. Brand Names:

Synonyms:

Generic Available:

Canadian Brand Names:

Use:

Cream/suspension: Treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), tinea corporis (ringworm), cutaneous candidiasis, and tinea versicolor (pityriasis)

Gel: Treatment of tinea pedis (athlete's foot), tinea corporis (ringworm); seborrheic dermatitis of the scalp

Lacquer (solution): Topical treatment of mild-to-moderate onychomycosis of the fingernails and toenails due to Trichophyton rubrum (not involving the lunula) and the immediately-adjacent skin

Shampoo: Treatment of seborrheic dermatitis of the scalp

Pregnancy Risk Factor:

Pregnancy Implications:

Lactation:

Contraindications:

Warnings/Precautions:

Adverse Reactions:

>10%: Local: Burning sensation (gel: 34%; 1% with other forms)

1% to 10%:

Central nervous system: Headache

Dermatologic: Erythema, nail disorder, pruritus, rash

Local: Irritation, redness, or pain

<1%: Alopecia, dry skin, facial edema

Drug Interactions:

Stability:

Cream, suspension: Store between 5°C to 25°C (41°F to 77°F)

Lacquer (solution): Store at room temperature of 15°C to 30°C (59°F to 86°F); protect from light. Flammable; keep away from heat and flame.

Gel, shampoo: Store at room temperature of 15°C to 30°C (59°F to 86°F)

Mechanism of Action:

Pharmacodynamics/Kinetics:

Absorption: Cream, solution: <2% through intact skin; increased with gel; <5% with lacquer

Distribution: Scalp application: To epidermis, corium (dermis), including hair, hair follicles, and sebaceous glands

Protein binding: 94% to 98%

Half-life elimination: Biologic: 1.7 hours (solution); elimination: 5.5 hours (gel)

Excretion: Urine (gel: 3% to 10%); feces (small amounts)

Dosage:

Children >10 years and Adults: Tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis, and tinea versicolor: Cream/suspension: Apply twice daily, gently massage into affected areas; if no improvement after 4 weeks of treatment, re-evaluate the diagnosis

Children >16 years and Adults:

Tinea pedis, tinea corporis, seborrheic dermatitis of the scalp: Gel: Apply twice daily, gently massage into affected areas and surrounding skin; if no improvement after 4 weeks of treatment, re-evaluate diagnosis

Seborrheic dermatitis of the scalp: Shampoo: Apply to wet hair, lather, and leave in place ~3 minute; rinse. Repeat twice weekly for 4 weeks; allow a minimum of 3 days between applications.

Onychomycosis of the fingernails and toenails: Children 12 years and Adults: Lacquer (solution): Apply to adjacent skin and affected nails daily (as a part of a comprehensive management program for onychomycosis). Remove with alcohol every 7 days

Administration:

Cream, suspension: Gently massage into affected areas.

Gel: Gently massage into affected areas and adjacent skin.

Lacquer (solution): Apply evenly over nail and surrounding skin at bedtime (or allow 8 hours before washing); apply daily over previous coat for 7 days; after 7 days, may remove with alcohol and continue cycle.

Shampoo: Apply to wet hair; lather and leave in place for ~3 minutes; rinse.

Patient Education:

Dental Health: Effects on Dental Treatment:

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

Mental Health: Effects on Mental Status:

Mental Health: Effects on Psychiatric Treatment:

Dosage Forms:

Cream, as olamine (Loprox®): 0.77% (15 g, 30 g, 90 g)

Gel (Loprox®): 0.77% (30 g, 45 g, 100 g)

Shampoo (Loprox®): 1% (120 mL)

Solution, topical [nail lacquer] (Penlac®): 8% (6.6 mL)

Suspension, topical, as olamine (Loprox®): 0.77% (30 mL, 60 mL)

International Brand Names: