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Ciprofloxacin and Hydrocortisone


Pronunciation

 (sip roe FLOKS a sin & hye droe KOR ti sone)


U.S. Brand Names

 Cipro® HC


Synonyms

 Hydrocortisone and Ciprofloxacin


Generic Available

 No


Canadian Brand Names

 Cipro® HC


Use

 Treatment of acute otitis externa, sometimes known as "swimmer's ear"


Drug Interactions

Ciprofloxacin: Inhibits CYP1A2 (strong), 3A4 (weak)

Hydrocortisone: Substrate of CYP3A4 (minor); Induces CYP3A4 (weak)

Also see individual agents.


Pharmacodynamics/Kinetics

 See individual agents.


Dosage

 Children >1 year of age and Adults: Otic: The recommended dosage for all patients is three drops of the suspension in the affected ear twice daily for seven day; twice-daily dosing schedule is more convenient for patients than that of existing treatments with hydrocortisone, which are typically administered three or four times a day; a twice-daily dosage schedule may be especially helpful for parents and caregivers of young children


Patient Education

 Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. Consult prescriber if breast-feeding.


Dental Health: Effects on Dental Treatment

 No significant effects or complications reported


Dental Health: Vasoconstrictor/Local Anesthetic Precautions

 No information available to require special precautions


Mental Health: Effects on Mental Status

 None reported


Mental Health: Effects on Psychiatric Treatment

 None reported


Dosage Forms

 Suspension, otic: Ciprofloxacin hydrochloride 0.2% and hydrocortisone 1% (10 mL) [contains benzyl alcohol]


International Brand Names

 Cipro® HC (CA)


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