Pronunciation:

(kloe BAY ta sol)

U.S. Brand Names:

Synonyms:

Generic Available:

Canadian Brand Names:

Use:

Pregnancy Risk Factor:

Pregnancy Implications:

Lactation:

Contraindications:

Warnings/Precautions:

Adverse Reactions:

Endocrine & metabolic: Adrenal suppression, Cushing's syndrome, hyperglycemia

Local: Application site: Burning, cracking/fissuring of the skin, dryness, erythema, folliculitis, irritation, numbness, pruritus, skin atrophy, stinging, telangiectasia

Renal: Glucosuria

Effects reported with other high-potency topical steroids: Acneiform eruptions, allergic contact dermatitis, hypertrichosis, hypopigmentation, maceration of the skin, miliaria, perioral dermatitis, secondary infection

Drug Interactions:

Stability:

Cream, emollient cream, ointment: Store at room temperature, between 15°C to 30°C (59°F to 86°F); do not refrigerate

Foam: Store at room temperature; do not expose to temperatures >49°C (120°F); avoid fire, flame, or smoking during and immediately following application

Gel: Store between 2°C to 30°C (36°F to 86°F)

Lotion: Store at room temperature of 20°C to 25°C (68°F to 77°F).

Solution: Store between 4°C to 25°C (39°F to 77°F); do not use near an open flame

Mechanism of Action:

Pharmacodynamics/Kinetics:

Absorption: Percutaneous absorption is variable and dependent upon many factors including vehicle used, integrity of epidermis, dose, and use of occlusive dressings

Metabolism: Hepatic

Excretion: Urine and feces

Dosage:

Children <12 years: Use is not recommended

Children 12 years and Adults:

Steroid-responsive dermatoses:

Cream, emollient cream, gel, lotion, ointment: Apply twice daily for up to 2 weeks (maximum dose: 50 g/week)

Foam, solution: Apply to affected scalp twice daily for up to 2 weeks (maximum dose: 50 g/week or 50 mL/week)

Mild to moderate plaque-type psoriasis of nonscalp areas: Foam: Apply to affected area twice daily for up to 2 weeks (maximum dose: 50 g/week); do not apply to face or intertriginous areas

Children 16 years and Adults: Moderate to severe plaque-type psoriasis: Emollient cream, lotion: Apply twice daily for up to 2 weeks, has been used for up to 4 weeks when application is <10% of body surface area; use with caution (maximum dose: 50 g/week)

Administration:

Cream, gel, lotion, ointment, solution: Apply the smallest amount that will cover affected area. Do not apply to face or intertriginous areas. Total dose should not exceed 50 g/week (or 50 mL/week of lotion or solution).

Foam: Turn can upside down and spray a small amount (golf-ball size) of foam into the cap or another cool surface. If the can is warm or foam is runny, place can under cold, running water. If fingers are warm, rinse with cool water and dry prior to handling (foam will melt on contact with warm skin). Massage foam into affected area.

Monitoring Parameters:

Patient Education:

Cream, gel, lotion, ointment, solution: Apply the smallest amount that will cover affected area. Do not apply to face. A thin film is effective; apply sparingly and rub in lightly.

Foam: Turn can upside down and spray a small amount (golf-ball size) of foam into the cap or another cool surface. If the can is warm or foam is runny, place can under cold, running water. If fingers are warm, rinse with cool water and dry prior to handling (foam will melt on contact with warm skin). Gently massage foam into affected area until foam disappears.

Pregnancy/breast-feeding precautions: Inform prescriber if you are pregnant. Consult prescriber if breast-feeding.

Nursing Implications:

Dental Health: Effects on Dental Treatment:

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

Mental Health: Effects on Mental Status:

Mental Health: Effects on Psychiatric Treatment:

Dosage Forms:

Cream, as propionate: 0.05% (15 g, 30 g, 45 g, 60 g)

Cormax®: 0.05% (15 g, 30 g, 45 g)

Embeline™, Temovate®: 0.05% (15 g, 30 g, 45 g, 60 g)

Cream, as propionate [in emollient base]: 0.05% (15 g, 30 g, 60 g)

Embeline™ E, Temovate E®: 0.05% (15 g, 30 g, 60 g)

Foam, topical, as propionate [for scalp application] (Olux®): 0.05% (50 g, 100 g) [contains ethanol 60%]

Gel, as propionate (Clobevate®, Embeline™; Temovate®): 0.05% (15 g, 30 g, 60 g)

Lotion, as propionate (Clobex™): 0.05% (30 mL, 59 mL)

Ointment, as propionate: 0.05% (15 g, 30 g, 45 g, 60 g)

Cormax®: 0.05% (15 g, 45 g)

Embeline™, Temovate®: 0.05% (15 g, 30 g, 45 g, 60 g)

Solution, topical, as propionate [for scalp application] (Cormax®, Embeline™, Temovate®): 0.05% (25 mL, 50 mL) [contains isopropyl alcohol 40%]

International Brand Names: