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Pronunciation:

(SYE kli zeen)

U.S. Brand Names:

Marezine® [OTC]

Synonyms:

Cyclizine Hydrochloride; Cyclizine Lactate

Generic Available:

Use:

Prevention and treatment of nausea, vomiting, and vertigo associated with motion sickness; control of postoperative nausea and vomiting

Pregnancy Risk Factor:

Contraindications:

Hypersensitivity to cyclizine or any component of the formulation

Adverse Reactions:

>10%:

Central nervous system: Drowsiness

Gastrointestinal: Xerostomia

1% to 10%:

Central nervous system: Headache

Dermatologic: Dermatitis

Gastrointestinal: Nausea

Genitourinary: Urinary retention

Ocular: Diplopia

Renal: Polyuria

Drug Interactions:

Increased effect/toxicity with CNS depressants, ethanol

Ethanol/Nutrition/Herb Interactions:

Ethanol: Avoid ethanol (may increase CNS depression).

Mechanism of Action:

Cyclizine is a piperazine derivative with properties of histamines. The precise mechanism of action in inhibiting the symptoms of motion sickness is not known. It may have effects directly on the labyrinthine apparatus and central actions on the labyrinthine apparatus and on the chemoreceptor trigger zone. Cyclizine exerts a central anticholinergic action.

Dosage:

Oral:

Children 6-12 years: 25 mg up to 3 times/day

Adults: 50 mg taken 30 minutes before departure, may repeat in 4-6 hours if needed, up to 200 mg/day

Patient Education:

May cause drowsiness, may impair judgment and coordination; avoid alcohol; drink plenty of fluids for dry mouth and to prevent constipation

Nursing Implications:

Monitor CNS effects or unusual movements

Dental Health: Effects on Dental Treatment:

Key adverse event(s) related to dental treatment: Xerostomia (normal salivary flow resumes upon discontinuation).

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

Drowsiness is common

Mental Health: Effects on Psychiatric Treatment:

Concurrent use with psychotropics may exacerbate the dry mouth and sedation commonly seen with cyclizine

Dosage Forms:

Tablet, as hydrochloride: 50 mg

International Brand Names:

Aculoid® (ZA); Cyclizine FNA® (NL); Echnatol® (AT); Marezine® (HK); Marzine® (CH, DK, FI, NO); Medazine® (ZA); Nauzine® (ZA); Triazine Tablets® (ZA); Valoid® (GB, IE); Valoid® [inj.] (GB, IE, NZ, ZA)

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