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Pronunciation:

(dye klor FEN a mide)

U.S. Brand Names:

Daranide®

Synonyms:

Diclofenamide

Generic Available:

Canadian Brand Names:

Daranide®

Use:

Adjunct in treatment of open-angle glaucoma and perioperative treatment for angle-closure glaucoma

Pregnancy Risk Factor:

Contraindications:

Hypersensitivity to dichlorphenamide or any component of the formulation; severe pulmonary obstruction; severe renal impairment

Warnings/Precautions:

Chemical similarities are present among sulfonamides, sulfonylureas, carbonic anhydrase inhibitors, thiazides, and loop diuretics (except ethacrynic acid). In patients with allergy to one of these compounds, a risk of cross-reaction exists; avoid use when previous reaction has been severe.

Adverse Reactions:

>10%:

Central nervous system: Fatigue, malaise

Gastrointestinal: Diarrhea, anorexia, metallic taste

Genitourinary: Polyuria

1% to 10%:

Central nervous system: Mental depression, drowsiness

Renal: Renal calculi

Drug Interactions:

Increased lithium excretion and altered excretion of other drugs by alkalinization of the urine

Dosage:

Adults: Oral: 100-200 mg to start followed by 100 mg every 12 hours until desired response is obtained; maintenance dose: 25-50 mg 1-3 times/day

Patient Education:

Report numbness or tingling of extremities to physician; ability to perform tasks requiring mental alertness and/or physical coordination may be impaired; take with food if GI upset occurs; notify if flank pain or rash occurs

Nursing Implications:

Monitor electrolytes

Dental Health: Effects on Dental Treatment:

Key adverse event(s) related to dental treatment: Metallic taste.

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

Sedation is common; may cause depression

Mental Health: Effects on Psychiatric Treatment:

May rarely cause bone marrow suppression; use caution with clozapine and carbamazepine; may increase the excretion of lithium but should not be used to treat lithium toxicity

Dosage Forms:

Tablet: 50 mg

International Brand Names:

Antidrasi® (IT); Daranide® (CA); Diclofenamid® (DE); Fenamide® (IT); Glauconide® (ES); Glaumid® (IT); Oratrol® (BE, CZ, HK, LU)

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