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Pronunciation:

(dye FLOR a sone)

U.S. Brand Names:

ApexiCon™; ApexiCon™ E; Florone®; Maxiflor® [DSC]; Psorcon®; Psorcon® e™

Synonyms:

Diflorasone Diacetate

Generic Available:

Yes

Canadian Brand Names:

Florone®; Psorcon®

Use:

Relieves inflammation and pruritic symptoms of corticosteroid-responsive dermatosis (high to very high potency topical corticosteroid)

Maxiflor®: High potency topical corticosteroid

Psorcon™: Very high potency topical corticosteroid

Pregnancy Risk Factor:

Contraindications:

Hypersensitivity to diflorasone

Warnings/Precautions:

Use with caution in patients with impaired circulation; skin infections

Adverse Reactions:

<1%: Itching, folliculitis, maceration, burning, dryness, muscle atrophy, arthralgia, secondary infection

Overdosage/Toxicology:

Symptoms of overdose include moon face, central obesity, hypertension, diabetes, hyperlipidemia, peptic ulcer, increased susceptibility to infection, electrolyte and fluid imbalance, psychosis, hallucinations. When consumed in excessive quantities, systemic hypercorticism and adrenal suppression may occur; in those cases discontinuation and withdrawal of the corticosteroid should be done judiciously.

Drug Interactions:

No data reported

Mechanism of Action:

Decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability

Pharmacodynamics/Kinetics:

Absorption: Negligible, around 1% reaches dermal layers or systemic circulation; occlusive dressings increase absorption percutaneously

Metabolism: Primarily hepatic

Dosage:

Topical: Apply ointment sparingly 1-3 times/day; apply cream sparingly 2-4 times/day. Therapy should be discontinued when control is achieved; if no improvement is seen, reassessment of diagnosis may be necessary.

Patient Education:

A thin film of cream or ointment is effective; do not overuse. Do not use tight-fitting diapers or plastic pants on children being treated in the diaper area. Use only as prescribed, and for no longer than the period prescribed. Apply sparingly in light film. Rub in lightly. Avoid contact with eyes. Notify physician if condition being treated persists or worsens. Pregnancy precaution: Inform prescriber if you are pregnant.

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

None reported

Mental Health: Effects on Psychiatric Treatment:

None reported

Dosage Forms:

[DSC] = Discontinued product

Cream, as diacetate: 0.05% (15 g, 30 g, 60 g)

ApexiCon™ E, Florone®, Maxiflor® [DSC]: 0.05% (30 g, 60 g)

Psorcon® [DSC]: 0.05% (60 g)

Psorcon® e™: 0.05% (15 g, 30 g, 60 g)

Ointment, as diacetate: 0.05% (15 g, 30 g, 60 g)

ApexiCon™, Maxiflor® [DSC]: 0.05% (30 g, 60 g)

Psorcon®: 0.05% (60 g)

Psorcon® e™: 0.05% (15 g, 30 g, 60 g)

International Brand Names:

Florone® (CA); Psorcon® (CA)

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