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Pronunciation:

(dor ZOLE a mide & TYE moe lole)

U.S. Brand Names:

Cosopt®

Synonyms:

Timolol and Dorzolamide

Generic Available:

Canadian Brand Names:

Cosopt®

Use:

Lowers intraocular pressure to treat glaucoma in patients with ocular hypertension or open-angle glaucoma

Contraindications:

See individual agents.

Warnings/Precautions:

See Warnings/Precautions in individual monographs

Adverse Reactions:

See individual agents.

Drug Interactions:

Dorzolamide: Substrate (minor) of CYP2C8/9, 3A4

Timolol: Substrate of CYP2D6 (major); Inhibits CYP2D6 (weak)

Also see individual agents.

Pharmacodynamics/Kinetics:

See individual agents.

Dosage:

Adults: ophthalmic: One drop in eye(s) twice daily

Patient Education:

See individual agents.

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

May cause drowsiness, dizziness, or fatigue; may rarely cause anxiety, depression, or hallucinations

Mental Health: Effects on Psychiatric Treatment:

Barbiturates and carbamazepine may decrease the effects of beta-blockers

Dosage Forms:

Solution, ophthalmic: Dorzolamide 2% and timolol 0.5% (5 mL, 10 mL) [contains benzalkonium chloride]

International Brand Names:

Cosopt® (CA)

References

Mokhlesi B, Leikin JB, Murray P, et al, "Adult Toxicology in Critical Care: Part II: Specific Poisonings,"Chest, 2003, 123(3):897-922.

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