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Dorzolamide and Timolol


Pronunciation

 (dor ZOLE a mide & TYE moe lole)


U.S. Brand Names

 Cosopt®


Synonyms

 Timolol and Dorzolamide


Generic Available

 No


Canadian Brand Names

 Cosopt®


Use

 Lowers intraocular pressure to treat glaucoma in patients with ocular hypertension or open-angle glaucoma


Contraindications

 See individual agents.


Warnings/Precautions

 See Warnings/Precautions in individual monographs


Adverse Reactions

 See individual agents.


Drug Interactions

Dorzolamide: Substrate (minor) of CYP2C8/9, 3A4

Timolol: Substrate of CYP2D6 (major); Inhibits CYP2D6 (weak)

Also see individual agents.


Pharmacodynamics/Kinetics

 See individual agents.


Dosage

 Adults: ophthalmic: One drop in eye(s) twice daily


Patient Education

 See individual agents.


Dental Health: Effects on Dental Treatment

 No significant effects or complications reported


Dental Health: Vasoconstrictor/Local Anesthetic Precautions

 No information available to require special precautions


Mental Health: Effects on Mental Status

 May cause drowsiness, dizziness, or fatigue; may rarely cause anxiety, depression, or hallucinations


Mental Health: Effects on Psychiatric Treatment

 Barbiturates and carbamazepine may decrease the effects of beta-blockers


Dosage Forms

 Solution, ophthalmic: Dorzolamide 2% and timolol 0.5% (5 mL, 10 mL) [contains benzalkonium chloride]


References

Mokhlesi B, Leikin JB, Murray P, et al, "Adult Toxicology in Critical Care: Part II: Specific Poisonings," Chest , 2003, 123(3):897-922.


International Brand Names

 Cosopt® (CA)


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