U.S. Brand Names:

Spectazole®

Synonyms:

Econazole Nitrate

Generic Available:

Yes

Canadian Brand Names:

Ecostatin®; Spectazole™

Use:

Topical treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), tinea corporis (ringworm), tinea versicolor, and cutaneous candidiasis

Pregnancy Risk Factor:

C

Pregnancy Implications:

Do not use during the 1st trimester of pregnancy, unless essential to a patient's welfare; use during the second and third trimesters only if clearly needed

Lactation:

Excretion in breast milk unknown

Contraindications:

Hypersensitivity to econazole or any component of the formulation

Warnings/Precautions:

Discontinue drug if sensitivity or chemical irritation occurs; not for ophthalmic or intravaginal use

Drug Interactions:

Inhibits CYP2E1 (weak)

No drug interaction data reported

Mechanism of Action:

Alters fungal cell wall membrane permeability; may interfere with RNA and protein synthesis, and lipid metabolism

Dosage:

Children and Adults: Topical:

Tinea pedis, tinea cruris, tinea corporis, tinea versicolor: Apply sufficient amount to cover affected areas once daily

Cutaneous candidiasis: Apply sufficient quantity twice daily (morning and evening)

Duration of treatment: Candidal infections and tinea cruris, versicolor, and corporis should be treated for 2 weeks and tinea pedis for 1 month; occasionally, longer treatment periods may be required

Patient Education:

For external use only. Apply exactly as directed and for the length of time prescribed. Report if conditions worsens or persists or if infection occurs. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. Consult prescriber if breast-feeding.

Nursing Implications:

Candidal infections and tinea cruris, versicolor, and corporis should be treated for 2 weeks and tinea pedis for 1 month; occasionally, longer treatment periods may be required

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

None reported

Mental Health: Effects on Psychiatric Treatment:

None reported

Dosage Forms:

Cream, topical, as nitrate: 1% (15 g, 30 g, 85 g)

International Brand Names:

Amicel® (RO); Chemionazolo® (IT); Dermazole® (AU, HK, SG); Dermazol® (FR); Ecalin® (HR, RU, SI); Ecanol® (IN); Ecodax® (RU); Ecodergin® (IT); Ecoderm® (ZA); Ecomi® (IT, RO); Econal® (ZA); Econazolo Merck Generics® (IT); Econazolo Pliva® (IT); Econ® (RO, TH); Ecostatin-1® (GB); Ecostatin® (CA, GB, IE, NZ); Ecosteril® (IT); Ecotam® (ES); Ecozol® (BD); Ecreme (NZ); Epi-Pevaryl® (DE); Epi-Pevaryl P.v.® (DE); Fongéryl® (FR); Ganazolo® (IT); Gyno-Coryl® (JO, LB); Gyno-Pevaryl® (AT, BD, BE, BG, CH); Gyno Pevaryl® (CR); Gyno-Pevaryl® (CY, CZ, DE); Gyno Pevaryl® (DO); Gyno-Pevaryl® (EG, ES, FR, GB); Gyno Pevaryl® (GT); Gyno-Pevaryl® (HK); Gyno Pevaryl® (HN); Gyno-Pevaryl® (HU, IE, IL, JO, LB, LU, MT, NZ); Gyno Pevaryl® (PA); Gyno-Pevaryl® (PL, PT, RO, SG); Gyno Pevaryl® (SV); Gyno-Pevaryl® (SY); Gyno Pevaryl® (YU); Gyno-Pevaryl® (ZA); Gynoryl® (EC); Ifenec® (IT); Italconazol® (EC); Micocide® (AR); Micoespec® (ES); Mico Fitex® (AR); Micolis® (AR, CL); Micos® (IT); Micostyl® (BR, MX); Mitekol® (SI); Novo-Paramicon® (AR); Pevalip® (AT); Pevaryl® (AT, AU, BD, BE, BG, CH, CY, CZ, DK, ES, FI, FR, GB, HK, HU, IE, IL, IT, JO, LU, MT, NL, NO, NZ, PL, PT, RO, SE, YU, ZA); Pevaryl G® (HU); Pevaryl-Hautschampoo® (AT, BE); Pevaryl Lipogel® (AT, BE, CH, CR, DO, GT, HN, MX, PA, PL, SV); Pevaryl lotion® (FR); Pevaryl P.V.® (HK, PL); Pevazol® (PL); Pevisone® (BG); Polinazolo® (IT); Sebolith® (CH); Sinamida Econazol® (AR); Spectazole™ (CA)