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Pronunciation:

(flure an DREN oh lide)

U.S. Brand Names:

Cordran®; Cordran® SP

Synonyms:

Flurandrenolone

Generic Available:

Canadian Brand Names:

Cordran®

Use:

Inflammation of corticosteroid-responsive dermatoses [medium potency topical corticosteroid]

Pregnancy Risk Factor:

Contraindications:

Hypersensitivity to flurandrenolide or any component of the formulation; viral, fungal, or tubercular skin lesions

Warnings/Precautions:

Adverse systemic effects may occur when used on large areas of the body, denuded areas, for prolonged periods of time, with an occlusive dressing, and/or in infants or small children

Adverse Reactions:

Frequency not defined.

Cardiovascular: Intracranial hypertension

Dermatologic: Itching, dry skin, folliculitis, hypertrichosis, acneiform eruptions, hyperpigmentation, perioral dermatitis, allergic contact dermatitis, skin atrophy, striae, miliaria, acne, maceration of the skin

Endocrine & metabolic: Cushing's syndrome, growth retardation, HPA suppression

Local: Burning, irritation

Miscellaneous: Secondary infection

Overdosage/Toxicology:

When consumed in excessive quantities, systemic hypercorticism and adrenal suppression may occur; in those cases, discontinuation and withdrawal of the corticosteroid should be done judiciously

Drug Interactions:

No data reported

Mechanism of Action:

Decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability

Pharmacodynamics/Kinetics:

Absorption: Adequate with intact skin; repeated applications lead to depot effects on skin, potentially resulting in enhanced percutaneous absorption

Metabolism: Hepatic

Excretion: Urine; feces (small amounts)

Dosage:

Topical: Therapy should be discontinued when control is achieved; if no improvement is seen, reassessment of diagnosis may be necessary.

Children:

Ointment, cream: Apply sparingly 1-2 times/day

Tape: Apply once daily

Adults: Cream, lotion, ointment: Apply sparingly 2-3 times/day

Administration:

Avoid contact with eyes. Apply sparingly in a light film and rub in lightly. A thin film is effective; do not overuse. Do not use tight-fitting diapers or plastic pants on children being treated in the diaper area.

Patient Education:

A thin film is effective; do not overuse. Do not use tight-fitting diapers or plastic pants on children being treated in the diaper area. Use only as prescribed, and for no longer than the period prescribed. Apply sparingly in a light film and rub in lightly. Avoid contact with eyes. Notify physician if condition being treated persists or worsens. Pregnancy precaution: Inform prescriber if you are pregnant.

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Dosage Forms:

Cream, emulsified, as base (Cordran® SP): 0.025% (30 g, 60 g); 0.05% (15 g, 30 g, 60 g)

Lotion (Cordran®): 0.05% (15 mL, 60 mL)

Ointment (Cordran®): 0.025% (30 g, 60 g); 0.05% (15 g, 30 g, 60 g)

Tape, topical [roll] (Cordran®): 4 mcg/cm² (7.5 cm x 60 cm, 7.5 cm x 200 cm)

International Brand Names:

Cordran® (CA)

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