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Guaifenesin and Phenylephrine


Pronunciation

 (gwye FEN e sin & fen il EF rin)


U.S. Brand Names

 Aldex™; Amidal; Ami-Tex LA; Crantex ER; Crantex LA; Deconsal® II; Endal®; Entex®; Entex® ER; Entex® LA; Guaifed®; Guaifed-PD®; Liquibid-D; Liquibid-PD; PhenaVent™; PhenaVent™ D; PhenaVent™ Ped; Prolex™-D; Rescon GG; Sil-Tex; Sina-12X; SINUvent® PE


Synonyms

 Guaifenesin and Phenylephrine Tannate; Phenylephrine Hydrochloride and Guaifenesin


Generic Available

 Yes: Excludes suspension


Use

 Temporary relief of nasal congestion, sinusitis, rhinitis and hay fever; temporary relief of cough associated with upper respiratory tract conditions, especially when associated with dry, nonproductive cough


Pregnancy Risk Factor

 C


Pregnancy Implications

 Animal reproduction studies have not been conducted with this combination. See individual agents.


Lactation

 Enters breast milk/not recommended


Contraindications

 Hypersensitivity to guaifenesin, phenylephrine, sympathomimetic amines, or any component of the formulation; severe hypertension; severe cardiovascular disease; use with or within 2 weeks of discontinuing MAO inhibitor


Warnings/Precautions

 Use caution with hypertension, diabetes, cardiovascular disease, hyperthyroidism, increased intraocular pressure, prostatic hyperplasia or in the elderly. Use caution with chronic cough; re-evaluate if cough persist >7 days.


Adverse Reactions

 See individual agents.


Drug Interactions

 See individual agents.


Mechanism of Action

 See individual agents.


Pharmacodynamics/Kinetics

 See individual agents.


Dosage

 Oral:

Children 2-6 years:

Entex®, Rescon GG, Sil-Tex: 2.5 mL every 4-6 hours; maximum 10 mL/24 hours

Sina-12X suspension: 2.5-5 mL every 12 hours

Children 6-12 years:

Aldex™, Crantex LA, Liquibid-D, PhenaVent™ D, Sina-12X tablet: One-half tablet every 12 hours (maximum: 1 tablet/24 hours)

Deconsol® II: One capsule daily

Entex®, Rescon GG: 5 mL every 4-6 hours (maximum: 20 mL/24 hours)

Guaifed-PD®, PhenaVent™ Ped: One capsule every 12 hours

Liquibid-PD, SINUvent® PE: One tablet every 12 hours (maximum: 2 tablets/24 hours)

Prolex™D: One-half to 1 tablet every 12 hours

Sina-12X suspension: Refer to Adults dosing.

Children 12 years:

Aldex™, Crantex LA, Deconsol® II, Entex®, Entex® LA, Guaifed®, Guaifed-PD®, Liquibid-D, Liquibid-PD, PhenaVent™, PhenaVent™ D, PhenaVent™ Ped, Prolex™ D, Rescon GG, Sil-Tex, Sina-12X, SINUvent® PE: Refer to Adults dosing

Crantex ER, Entex® ER: One capsule every 12 hours

Adults:

Aldex™, Crantex LA, Liquibid-D, PhenaVent™ D: One tablet every 12 hours

Crantex ER, Entex® ER, Guaifed-PD®, PhenaVent™ Ped: 1-2 capsules every 12 hours

Deconsol® II: 1-2 capsules every 12 hours (maximum: 3 capsules/24 hours)

Endal®, Prolex™ D: 1-2 tablets every 12 hours

Entex®, Sil-Tex: 5-10 mL every 4-6 hours (maximum: 40 mL/24 hours)

Entex® LA, Guaifed®, PhenaVent™: One capsule every 12 hours (maximum: 2 capsules/24 hours)

Liquibid-PD, Sina-12X tablet: 1-2 tablets every 12 hours (maximum: 4 tablets/24 hours)

Rescon GG: 10 mL every 4-6 hours (maximum: 40 mL/24 hours)

Sina-12X suspension: 5-10 mL every 12 hours

SINUvent® PE: Two tablets every 12 hours


Administration

 Tablets and capsules should not be crushed or chewed. Capsules should not be opened.


Dietary Considerations

 May be taken with or without food. Taking with food, water or milk may help decrease gastric irritation.


Dental Health: Effects on Dental Treatment

 Key adverse event(s) related to dental treatment:

Guaifenesin: No significant effects or complications reported

Phenylephrine: Up to 10% of patients could experience tachycardia, palpitations, and xerostomia (normal salivary flow resumes upon discontinuation); use vasoconstrictor with caution


Dental Health: Vasoconstrictor/Local Anesthetic Precautions

 Use with caution since phenylephrine is a sympathomimetic amine which could interact with epinephrine to cause a pressor response


Mental Health: Effects on Mental Status

 Guaifenesin may cause drowsiness; phenylephrine may cause anxiety or restlessness


Mental Health: Effects on Psychiatric Treatment

 Concurrent use with psychotropics may produce additive sedation or lessen the effects of anxiolytics depending on whether the effects of guaifenesin or phenylephrine predominate; concurrent use with MAO inhibitors may result in hypertensive crisis; avoid combination


Dosage Forms

Capsule, variable release:

Crantex ER, Entex® ER: Guaifenesin 300 mg [immediate release] and phenylephrine hydrochloride 10 mg [extended release]

Deconsal® II: Guaifenesin 375 mg [immediate release] and phenylephrine hydrochloride 20 mg [extended release] [contains tartrazine]

Entex® LA: Guaifenesin 400 mg [immediate release] and phenylephrine hydrochloride 30 mg [extended release]

Guaifed®, PhenaVent™: Guaifenesin 400 mg [immediate release] and phenylephrine hydrochloride 15 mg [extended release]

Guaifed-PD®, PhenaVent™ Ped: Guaifenesin 200 mg [immediate release] and phenylephrine hydrochloride 7.5 mg [extended release]

Liquid: Guaifenesin 100 mg and phenylephrine hydrochloride 7.5 mg per 5 mL (480 mL)

Entex®, Sil-Tex: Guaifenesin 100 mg and phenylephrine hydrochloride 7.5 mg per 5 mL (480 mL) [alcohol free, dye-free, sugar free; punch flavor]

Rescon GG: Guaifenesin 100 mg and phenylephrine hydrochloride 5 mg per 5 mL (120 mL, 480 mL) [cherry orange-pineapple flavor]

Suspension (Sina-12X): Guaifenesin 100 mg and phenylephrine tannate 5 mg per 5 mL (120 mL) [contains benzoic acid; grape flavor]

Tablet:

Amidal: Guaifenesin 300 mg and phenylephrine hydrochloride 20 mg

Sina-12X: Guaifenesin 200 mg and phenylephrine tannate 25 mg

Tablet, extended release: Guaifenesin 600 mg and phenylephrine hydrochloride 20 mg; Guaifenesin 600 mg and phenylephrine hydrochloride 40 mg; Guaifenesin 1200 mg and phenylephrine hydrochloride 40 mg

Aldex™: Guaifenesin 650 mg and phenylephrine hydrochloride 25 mg

Ami-Tex LA: Guaifenesin 600 mg and phenylephrine hydrochloride 30 mg

Liquibid-D: Guaifenesin 600 mg and phenylephrine hydrochloride 40 mg

Liquibid-PD: Guaifenesin 275 mg and phenylephrine hydrochloride 25 mg

PhenaVent™ D: Guaifenesin 1200 mg and phenylephrine hydrochloride 40 mg

SINUvent® PE: Guaifenesin 600 mg and phenylephrine hydrochloride 15 mg

Tablet, sustained release: Guaifenesin 600 mg and phenylephrine hydrochloride 30 mg

Crantex-LA: Guaifenesin 600 mg and phenylephrine hydrochloride 30 mg [dye-free]

Prolex™D: Guaifenesin 600 mg and phenylephrine hydrochloride 20 mg [dye-free]

Tablet, timed release (Endal®): Guaifenesin 300 mg and phenylephrine hydrochloride 20 mg


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