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Pronunciation:

(nee oh MYE sin & deks a METH a sone)

U.S. Brand Names:

NeoDecadron®

Synonyms:

Dexamethasone and Neomycin

Generic Available:

Use:

Treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, lid, cornea, and anterior segment of the globe

Pregnancy Risk Factor:

Lactation:

Excretion in breast milk unknown

Contraindications:

Based on neomycin component: Hypersensitivity to neomycin or any component of the formulation, or other aminoglycosides; intestinal obstruction

Based on dexamethasone component: Hypersensitivity to dexamethasone or any component of the formulation; active untreated infections; ophthalmic use in viral, fungal, or tuberculosis diseases of the eye

Warnings/Precautions:

See individual agents.

Adverse Reactions:

<1%: Burning, local irritation or transient stinging; epithelial punctate keratitis, increased intraocular pressure, mydriasis, ptosis, and possible corneal or scleral malacia can occur

Drug Interactions:

Dexamethasone: Substrate of CYP3A4 (minor); Induces CYP2A6 (weak), 2B6 (weak), 2C8/9 (weak), 3A4 (weak)

Also see individual agents.

Stability:

Store in tight, light-resistant container

Pharmacodynamics/Kinetics:

See individual agents.

Dosage:

Ophthalmic: Instill 1-2 drops in eye(s) every 3-4 hours

Patient Education:

See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. Consult prescriber if breast-feeding.

Nursing Implications:

May cause sensitivity to light, can minimize by wearing sunglasses

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

None reported

Mental Health: Effects on Psychiatric Treatment:

None reported

Dosage Forms:

Solution, ophthalmic: Neomycin sulfate 0.35% [3.5 mg/mL] and dexamethasone sodium phosphate 0.1% [1 mg/mL] (5 mL) [contains benzalkonium chloride and sodium bisulfite]

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