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Neomycin, Colistin, Hydrocortisone, and Thonzonium


Pronunciation

 (nee oh MYE sin, koe LIS tin, hye droe KOR ti sone, & thon ZOE nee um)


U.S. Brand Names

 Coly-Mycin® S; Cortisporin®-TC


Synonyms

 Colistin, Neomycin, Hydrocortisone, and Thonzonium; Hydrocortisone, Neomycin, Colistin, and Thonzonium; Thonzonium, Neomycin, Colistin, and Hydrocortisone


Generic Available

 No


Use

 Treatment of superficial and susceptible bacterial infections of the external auditory canal; for treatment of susceptible bacterial infections of mastoidectomy and fenestration cavities


Contraindications

 Hypersensitivity to any component of the formulation and/or aminoglycosides; herpes simplex, vaccinia, varicella


Warnings/Precautions

 Prolonged treatment may result in overgrowth of nonsusceptible organisms. Discontinue if irritation occurs. Use caution in longstanding otitis media or tympanic perforation; risk of ototoxicity is increased. Do not use for longer than 10 days.


Adverse Reactions

 Frequency not defined.

Dermatologic: Hypersensitivity reaction, irritation

Otic: Ototoxicity (rare)


Drug Interactions

 Hydrocortisone: Substrate of CYP3A4 (minor); Induces CYP3A4 (weak)


Dosage

 Otic:

Calibrated dropper:

Children: 4 drops in affected ear 3-4 times/day

Adults: 5 drops in affected ear 3-4 times/day

Dropper bottle:

Children: 3 drops in affected ear 3-4 times/day

Adults: 4 drops in affected ear 3-4 times/day

Note: Alternatively, a cotton wick may be inserted in the ear canal and saturated with suspension every 4 hours; wick should be replaced at least every 24 hours


Patient Education

 Shake well before using.


Dental Health: Effects on Dental Treatment

 No significant effects or complications reported


Dental Health: Vasoconstrictor/Local Anesthetic Precautions

 No information available to require special precautions


Mental Health: Effects on Mental Status

 None reported


Mental Health: Effects on Psychiatric Treatment

 None reported


Dosage Forms

Suspension, otic [drops]:

Coly-Mycin® S: Neomycin 0.33%, colistin 0.3%, hydrocortisone acetate 1%, and thonzonium bromide 0.05% (5 mL) [contains thimerosal; packaged with dropper]

Cortisporin®-TC: Neomycin 0.33%, colistin 0.3%, hydrocortisone acetate 1%, and thonzonium bromide 0.05% (10 mL) [contains thimerosal; packaged with dropper]


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