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Neomycin and Dexamethasone


Pronunciation

 (nee oh MYE sin & deks a METH a sone)


U.S. Brand Names

 NeoDecadron®


Synonyms

 Dexamethasone and Neomycin


Generic Available

 No


Use

 Treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, lid, cornea, and anterior segment of the globe


Pregnancy Risk Factor

 C


Lactation

 Excretion in breast milk unknown


Contraindications

Based on neomycin component: Hypersensitivity to neomycin or any component of the formulation, or other aminoglycosides; intestinal obstruction

Based on dexamethasone component: Hypersensitivity to dexamethasone or any component of the formulation; active untreated infections; ophthalmic use in viral, fungal, or tuberculosis diseases of the eye


Warnings/Precautions

 See individual agents.


Adverse Reactions

 <1%: Burning, local irritation or transient stinging; epithelial punctate keratitis, increased intraocular pressure, mydriasis, ptosis, and possible corneal or scleral malacia can occur


Drug Interactions

 Dexamethasone: Substrate of CYP3A4 (minor); Induces CYP2A6 (weak), 2B6 (weak), 2C8/9 (weak), 3A4 (weak)

Also see individual agents.


Stability

 Store in tight, light-resistant container


Pharmacodynamics/Kinetics

 See individual agents.


Dosage

 Ophthalmic: Instill 1-2 drops in eye(s) every 3-4 hours


Patient Education

 See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. Consult prescriber if breast-feeding.


Nursing Implications

 May cause sensitivity to light, can minimize by wearing sunglasses


Dental Health: Effects on Dental Treatment

 No significant effects or complications reported


Dental Health: Vasoconstrictor/Local Anesthetic Precautions

 No information available to require special precautions


Mental Health: Effects on Mental Status

 None reported


Mental Health: Effects on Psychiatric Treatment

 None reported


Dosage Forms

 Solution, ophthalmic: Neomycin sulfate 0.35% [3.5 mg/mL] and dexamethasone sodium phosphate 0.1% [1 mg/mL] (5 mL) [contains benzalkonium chloride and sodium bisulfite]


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