Pronunciation:

(nee oh MYE sin, pol i MIKS in bee, & hye droe KOR ti sone)

U.S. Brand Names:

Synonyms:

Generic Available:

Canadian Brand Names:

Use:

Pregnancy Risk Factor:

Contraindications:

Adverse Reactions:

Dermatologic: Contact dermatitis, erythema, rash, urticaria

Local: Burning, itching, swelling, pain, stinging

Ocular: Intraocular pressure increased, glaucoma, cataracts, conjunctival erythema, transient irritation, burning, stinging, itching, inflammation, angioneurotic edema, urticaria, vesicular and maculopapular dermatitis

Otic: Ototoxicity

Miscellaneous: Hypersensitivity, sensitization to neomycin, secondary infection

Drug Interactions:

Also see individual agents.

Mechanism of Action:

Pharmacodynamics/Kinetics:

Dosage:

Otic solution is used only for swimmer's ear (infections of external auditory canal)

Otic:

Children: Instill 3 drops into affected ear 3-4 times/day

Adults: Instill 4 drops 3-4 times/day; otic suspension is the preferred otic preparation

Children and Adults:

Ophthalmic: Drops: Instill 1-2 drops 2-4 times/day, or more frequently as required for severe infections; in acute infections, instill 1-2 drops every 15-30 minutes gradually reducing the frequency of administration as the infection is controlled

Topical: Apply a thin layer 1-4 times/day. Therapy should be discontinued when control is achieved; if no improvement is seen, reassessment of diagnosis may be necessary.

Administration:

Patient Education:

Otic: Hold container in hand to warm; if drops are in suspension form, shake well for approximately 10 seconds, lie on your side with affected ear up; for adults hold the ear lobe up and back, for children hold the ear lobe down and back; instill drops in ear without inserting dropper into ear; maintain tilted ear for 2 minutes

Ophthalmic: May cause sensitivity to bright light; may cause temporary blurring of vision or stinging following administration, but discontinue product and see prescriber if problems persist or increase; to use, tilt head back and place medication in conjunctival sac and close eyes; apply light pressure on lacrimal sac for 1 minute

Cream: Discontinue product if irritation persists or increases

Nursing Implications:

Dental Health: Effects on Dental Treatment:

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

Mental Health: Effects on Mental Status:

Mental Health: Effects on Psychiatric Treatment:

Dosage Forms:

Cream, topical (Cortisporin®): Neomycin 3.5 mg, polymyxin B 10,000 units, and hydrocortisone 5 mg per g (7.5 g)

Solution, otic (AntibiOtic® Ear; Cortisporin®): Neomycin 3.5 mg, polymyxin B 10,000 units, and hydrocortisone 10 mg per mL (10 mL) [contains potassium metabisulfite]

Suspension, ophthalmic (Cortisporin®): Neomycin 3.5 mg, polymyxin B 10,000 units, and hydrocortisone 10 mg per mL (7.5 mL) [contains thimerosal]

Suspension, otic: Neomycin 3.5 mg, polymyxin B 10,000 units, and hydrocortisone 10 mg per mL (10 mL)

AntibiOtic® Ear, Cortisporin®: Neomycin 3.5 mg, polymyxin B 10,000 units, and hydrocortisone 10 mg per mL (10 mL) [contains thimerosal]

PediOtic®: Neomycin 3.5 mg, polymyxin B 10,000 units, and hydrocortisone 10 mg per mL (7.5 mL) [contains thimerosal]

International Brand Names: