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Nystatin and Triamcinolone


Pronunciation

 (nye STAT in & trye am SIN oh lone)


U.S. Brand Names

 Mycolog®-II [DSC]


Synonyms

 Triamcinolone and Nystatin


Generic Available

 Yes


Use

 Treatment of cutaneous candidiasis


Pregnancy Risk Factor

 C


Lactation

 Excretion in breast milk unknown


Contraindications

 Hypersensitivity to nystatin, triamcinolone, or any component of the formulation


Warnings/Precautions

 Avoid use of occlusive dressings; limit therapy to least amount necessary for effective therapy, pediatric patients may be more susceptible to HPA axis suppression due to larger BSA to weight ratio


Adverse Reactions

 1% to 10%:

Dermatologic: Dryness, folliculitis, hypertrichosis, acne, hypopigmentation, allergic dermatitis, maceration of the skin, skin atrophy

Local: Burning, itching, irritation

Miscellaneous: Increased incidence of secondary infection


Drug Interactions

 No data reported


Mechanism of Action

 Nystatin is an antifungal agent that binds to sterols in fungal cell membrane, changing the cell wall permeability allowing for leakage of cellular contents. Triamcinolone is a synthetic corticosteroid; it decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It suppresses the immune system reducing activity and volume of the lymphatic system. It suppresses adrenal function at high doses.


Pharmacodynamics/Kinetics

 See individual agents.


Dosage

 Children and Adults: Topical: Apply sparingly 2-4 times/day. Therapy should be discontinued when control is achieved; if no improvement is seen, reassessment of diagnosis may be necessary.


Administration

 External use only; do not use on open wounds; apply sparingly to occlusive dressings; should not be used in the presence of open or weeping lesions


Patient Education

 See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. Consult prescriber if breast-feeding.


Dental Health: Effects on Dental Treatment

 No significant effects or complications reported


Dental Health: Vasoconstrictor/Local Anesthetic Precautions

 No information available to require special precautions


Mental Health: Effects on Mental Status

 None reported


Mental Health: Effects on Psychiatric Treatment

 None reported


Dosage Forms

 [DSC] = Discontinued product

Cream (Mycolog®-II [DSC]): Nystatin 100,000 units and triamcinolone acetonide 0.1% (15 g, 30 g, 60 g)

Ointment: Nystatin 100,000 units and triamcinolone acetonide 0.1% (15 g, 30 g, 60 g)

Mycolog®-II: Nystatin 100,000 units and triamcinolone acetonide 0.1% (15 g, 30 g, 60 g) [DSC]


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