Print this page
 Email this page

 Connect with UMMC on:
 Twitter
 Facebook
 YouTube
iPhone

 Share this page:

Bookmark and Share

Home > Medical Reference > Encyclopedia (English)



 

Video details

[ Flash player icon ] Please install flash player to see this video.

Hospital Virtual Tour

Click to take a virtual tour

Related Content


 

U.S. Brand Names:

Norgesic™; Norgesic™ Forte; Orphengesic; Orphengesic Forte

Synonyms:

Aspirin, Orphenadrine, and Caffeine; Caffeine, Orphenadrine, and Aspirin

Generic Available:

Yes

Canadian Brand Names:

Norgesic™; Norgesic™ Forte

Use:

Relief of discomfort associated with skeletal muscular conditions

Pregnancy Risk Factor:

D

Lactation:

Enters breast milk/use caution due to aspirin content

Contraindications:

Hypersensitivity to any component of the formulation; glaucoma; pyloric obstruction; duodenal obstruction; achalasia; prostatic hyperplasia; bladder obstruction; myasthenia gravis

Drug Interactions:

Orphenadrine: Substrate (minor) of CYP1A2, 2B6, 2D6, 3A4; Inhibits CYP1A2 (weak), 2A6 (weak), 2B6 (weak), 2C8/9 (weak), 2C19 (weak), 2D6 (weak), 2E1 (weak), 3A4 (weak)

Aspirin: Substrate of CYP2C8/9 (minor)

Caffeine: Substrate of CYP1A2 (major), 2C8/9 (minor), 2D6 (minor), 2E1 (minor), 3A4 (minor); Inhibits CYP1A2 (weak), 3A4 (moderate)

Also see individual monographs for Orphenadrine and Aspirin.

Pharmacodynamics/Kinetics:

See individual agents.

Dosage:

Oral: 1-2 tablets 3-4 times/day

Patient Education:

Refer to Orphenadrine and Aspirin Monographs (see Related Information). Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. Consult prescriber if breast-feeding.

Dental Health: Effects on Dental Treatment:

The peripheral anticholinergic effects of orphenadrine may decrease or inhibit salivary flow; normal salivation will return with cessation of drug therapy.

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

Drowsiness and dizziness are common; may rarely cause hallucinations

Mental Health: Effects on Psychiatric Treatment:

May rarely cause aplastic anemia; use caution with clozapine and carbamazepine; concurrent use with psychotropics may produce additive sedation

Dosage Forms:

Tablet: Orphenadrine citrate 25 mg, aspirin 385 mg, and caffeine 30 mg; orphenadrine citrate 50 mg, aspirin 770 mg, and caffeine 60 mg

Norgesic™, Orphengesic: Orphenadrine citrate 25 mg, aspirin 385 mg, and caffeine 30 mg

Norgesic™ Forte, Orphengesic Forte: Orphenadrine citrate 50 mg, aspirin 770 mg, and caffeine 60 mg

International Brand Names:

Norgesic™ (CA); Norgesic™ Forte (CA)

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
adam.com