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Orphenadrine, Aspirin, and Caffeine


Pronunciation

 (or FEN a dreen, AS pir in, & KAF een)


U.S. Brand Names

 Norgesic™; Norgesic™ Forte; Orphengesic; Orphengesic Forte


Synonyms

 Aspirin, Orphenadrine, and Caffeine; Caffeine, Orphenadrine, and Aspirin


Generic Available

 Yes


Canadian Brand Names

 Norgesic™; Norgesic™ Forte


Use

 Relief of discomfort associated with skeletal muscular conditions


Pregnancy Risk Factor

 D


Lactation

 Enters breast milk/use caution due to aspirin content


Contraindications

 Hypersensitivity to any component of the formulation; glaucoma; pyloric obstruction; duodenal obstruction; achalasia; prostatic hyperplasia; bladder obstruction; myasthenia gravis


Drug Interactions

Orphenadrine: Substrate (minor) of CYP1A2, 2B6, 2D6, 3A4; Inhibits CYP1A2 (weak), 2A6 (weak), 2B6 (weak), 2C8/9 (weak), 2C19 (weak), 2D6 (weak), 2E1 (weak), 3A4 (weak)

Aspirin: Substrate of CYP2C8/9 (minor)

Caffeine: Substrate of CYP1A2 (major), 2C8/9 (minor), 2D6 (minor), 2E1 (minor), 3A4 (minor); Inhibits CYP1A2 (weak), 3A4 (moderate)

Also see individual monographs for Orphenadrine and Aspirin.


Pharmacodynamics/Kinetics

 See individual agents.


Dosage

 Oral: 1-2 tablets 3-4 times/day


Patient Education

 Refer to Orphenadrine and Aspirin Monographs (see Related Information). Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. Consult prescriber if breast-feeding.


Dental Health: Effects on Dental Treatment

 The peripheral anticholinergic effects of orphenadrine may decrease or inhibit salivary flow; normal salivation will return with cessation of drug therapy.


Dental Health: Vasoconstrictor/Local Anesthetic Precautions

 No information available to require special precautions


Mental Health: Effects on Mental Status

 Drowsiness and dizziness are common; may rarely cause hallucinations


Mental Health: Effects on Psychiatric Treatment

 May rarely cause aplastic anemia; use caution with clozapine and carbamazepine; concurrent use with psychotropics may produce additive sedation


Dosage Forms

Tablet: Orphenadrine citrate 25 mg, aspirin 385 mg, and caffeine 30 mg; orphenadrine citrate 50 mg, aspirin 770 mg, and caffeine 60 mg

Norgesic™, Orphengesic: Orphenadrine citrate 25 mg, aspirin 385 mg, and caffeine 30 mg

Norgesic™ Forte, Orphengesic Forte: Orphenadrine citrate 50 mg, aspirin 770 mg, and caffeine 60 mg


International Brand Names

 Norgesic™ (CA); Norgesic™ Forte (CA)


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