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Oxiconazole


Pronunciation

 (oks i KON a zole)


U.S. Brand Names

 Oxistat®


Synonyms

 Oxiconazole Nitrate


Generic Available

 No


Canadian Brand Names

 Oxistat®; Oxizole®


Use

 Treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm)


Pregnancy Risk Factor

 B


Pregnancy Implications

 Teratogenic effects were not observed in animal studies. There are no adequate or well-controlled studies in pregnant women.


Lactation

 Enters breast milk/use caution


Contraindications

 Hypersensitivity to oxiconazole or any component of the formulation; not for ophthalmic use


Warnings/Precautions

 May cause irritation during therapy; if a sensitivity to oxiconazole occurs, therapy should be discontinued; avoid contact with eyes or vagina


Adverse Reactions

 1% to 10%:

Dermatologic: Itching, erythema

Local: Transient burning, local irritation, stinging, dryness


Stability

 Store between 15°C to 30°C (59°F to 86°F). Shake lotion well before use.


Mechanism of Action

 The cytoplasmic membrane integrity of fungi is destroyed by oxiconazole which exerts a fungicidal activity through inhibition of ergosterol synthesis. Effective for treatment of tinea pedis, tinea cruris, tinea corporis, and tinea versicolor. Active against Trichophyton rubrum , Trichophyton mentagrophytes , Trichophyton violaceum , Microsporum canis , Microsporum audouini , Microsporum gypseum , Epidermophyton floccosum , Candida albicans , and Malassezia furfur .


Pharmacodynamics/Kinetics

Absorption: In each layer of the dermis; very little systemically after one topical dose

Distribution: To each layer of the dermis; enters breast milk

Excretion: Urine (<0.3%)


Dosage

 Topical:

Children and Adults:

Tinea corporis/tinea cruris: Cream, lotion: Apply to affected areas 1-2 times daily for 2 weeks

Tinea pedis: Cream, lotion: Apply to affected areas 1-2 times daily for 1 month

Adults: Tinea versicolor: Cream: Apply to affected areas once daily for 2 weeks


Patient Education

 External use only; discontinue if sensitivity or chemical irritation occurs, contact prescriber if condition fails to improve in 3-4 days


Dental Health: Effects on Dental Treatment

 No significant effects or complications reported


Dental Health: Vasoconstrictor/Local Anesthetic Precautions

 No information available to require special precautions


Mental Health: Effects on Mental Status

 None reported


Mental Health: Effects on Psychiatric Treatment

 None reported


Dosage Forms

Cream, as nitrate: 1% (15 g, 30 g, 60 g)

Lotion, as nitrate: 1% (30 mL)


International Brand Names

 Fonx® (FR); Gyno-Liderman® (AT); Gyno-Myfungar® (CZ, MX); Liderman® (AT); Myfungar® (CH, CZ, DE, MX, RU); Oceral® (BR, CH, DE, TR); Oxistat® (CA, CR, DO, GT, HN, MX, PA, SV); Oxizole® (CA); Salongo® (ES); Salongo Vaginal® (ES)


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