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Pronunciation:

(oks i KON a zole)

U.S. Brand Names:

Oxistat®

Synonyms:

Oxiconazole Nitrate

Generic Available:

Canadian Brand Names:

Oxistat®; Oxizole®

Use:

Treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm)

Pregnancy Risk Factor:

Pregnancy Implications:

Teratogenic effects were not observed in animal studies. There are no adequate or well-controlled studies in pregnant women.

Lactation:

Enters breast milk/use caution

Contraindications:

Hypersensitivity to oxiconazole or any component of the formulation; not for ophthalmic use

Warnings/Precautions:

May cause irritation during therapy; if a sensitivity to oxiconazole occurs, therapy should be discontinued; avoid contact with eyes or vagina

Adverse Reactions:

1% to 10%:

Dermatologic: Itching, erythema

Local: Transient burning, local irritation, stinging, dryness

Stability:

Store between 15°C to 30°C (59°F to 86°F). Shake lotion well before use.

Mechanism of Action:

The cytoplasmic membrane integrity of fungi is destroyed by oxiconazole which exerts a fungicidal activity through inhibition of ergosterol synthesis. Effective for treatment of tinea pedis, tinea cruris, tinea corporis, and tinea versicolor. Active against Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton violaceum, Microsporum canis, Microsporum audouini, Microsporum gypseum, Epidermophyton floccosum, Candida albicans, and Malassezia furfur.

Pharmacodynamics/Kinetics:

Absorption: In each layer of the dermis; very little systemically after one topical dose

Distribution: To each layer of the dermis; enters breast milk

Excretion: Urine (<0.3%)

Dosage:

Topical:

Children and Adults:

Tinea corporis/tinea cruris: Cream, lotion: Apply to affected areas 1-2 times daily for 2 weeks

Tinea pedis: Cream, lotion: Apply to affected areas 1-2 times daily for 1 month

Adults: Tinea versicolor: Cream: Apply to affected areas once daily for 2 weeks

Patient Education:

External use only; discontinue if sensitivity or chemical irritation occurs, contact prescriber if condition fails to improve in 3-4 days

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

None reported

Mental Health: Effects on Psychiatric Treatment:

None reported

Dosage Forms:

Cream, as nitrate: 1% (15 g, 30 g, 60 g)

Lotion, as nitrate: 1% (30 mL)

International Brand Names:

Fonx® (FR); Gyno-Liderman® (AT); Gyno-Myfungar® (CZ, MX); Liderman® (AT); Myfungar® (CH, CZ, DE, MX, RU); Oceral® (BR, CH, DE, TR); Oxistat® (CA, CR, DO, GT, HN, MX, PA, SV); Oxizole® (CA); Salongo® (ES); Salongo Vaginal® (ES)

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