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Pronunciation:

(PAN kree a tin)

U.S. Brand Names:

Hi-Vegi-Lip® [OTC]; Kutrase®; Ku-Zyme®; Pan-2400™ [OTC]; Pancreatin 4X [OTC]; Pancreatin 8X [OTC]; Veg-Pancreatin 4X [OTC]

Generic Available:

Yes

Use:

Relief of functional indigestion due to enzyme deficiency or imbalance

Pregnancy Risk Factor:

Lactation:

Excretion in breast milk unknown/use caution

Contraindications:

Hypersensitivity to pork protein or any component of the formulation; acute pancreatitis or acute exacerbations of chronic pancreatic disease

Warnings/Precautions:

Some products are made from pork protein and should not be used if allergic to pork.

Adverse Reactions:

Frequency not defined.

Gastrointestinal: Loose stools (decrease dose)

Respiratory: Mucous membrane irritation or precipitation of asthma attack (due to inhalation of airborne powder)

Overdosage/Toxicology:

Overdose may lead to laxative effect. Treatment should be supportive.

Stability:

Store at controlled room temperature of 15°C to 30°C (59°F to 86°F); protect from humidity

Mechanism of Action:

An enzyme supplement, not a replacement, which contains a combination of lipase, amylase and protease. Enhances the digestion of proteins, starch and fat in the stomach and intestines.

Dosage:

Oral: Adults: Actual dose varies with condition of patient and is usually given with each meal or snack.

Ku-Zyme®: 1-2 capsules with each meal or snack

Kutrase®: 1 capsule with each meal or snack

Administration:

Oral: Swallow capsules/tablets whole; retention in the mouth before swallowing may cause mucosal irritation and stomatitis. Capsules may also be opened and sprinkled on soft food (do not chew).

Dietary Considerations:

Should be taken with a meal or snack. Capsules may be opened and sprinkled on soft food.

Patient Education:

Retention in the mouth before swallowing may cause mucosal irritation and stomatitis; do not crush or chew, swallow whole

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

None reported

Mental Health: Effects on Psychiatric Treatment:

None reported

Dosage Forms:

Capsule:

Kutrase®: Lipase 2400 units, protease 30,000 units, amylase 30,000 units

Ku-Zyme®: Lipase 1200 units, protease 15,000 units, amylase 15,000 units

Pan-2400™: Lipase 9816 units, protease 60,214 units, amylase 75,900 units [pancreatin 2400 mg]

Tablet:

Hi-Vegi-Lip®: Lipase 4800 units, amylase 60,000 units, protease 60,000 units [pancreatin 2400 mg; vegetable source]

Pancreatin 4X: Lipase 12,000 units, amylase 60,000 units, protease 60,000 units [pancreatin 2400 mg]

Pancreatin 8X: Lipase 22,500 units, amylase 180,000 units, protease 180,000 units [pancreatin 7200 mg]

Veg-Pancreatin 4X: Lipase 12,000 units, amylase 60,000 units, protease 60,000 units [pancreatin 2400 mg; vegetable source]

International Brand Names:

Bilipeptal mono® (DE); Cholospasminase® (DE); Cholspasminase® (DE); Combizym® (LU, NL, NO, PL, TH); Cotazym® (DE, ID); Creon® (AR, CH, EC); Creon Forte® (AR, NZ, SE); Créon® (FR); Creon® (GB, IE, LU, MX, NL, NZ, SE, SG, TH, ZA); Crezyme® (BD); Dispeptal® (IN); Enzyflat® (AT); Enzym-Lefax® (DE); Euflat-E® (DE); Gastrix® (CZ); Helopanzym® (AT); Hepa-Merz® (LU); Hevertozym® (DE); Kreon® (AT, BG, CZ, DE, ES, HU, PL, PT, RU, SI, TR); Licréase® (FR); Licrease® (RU); Lipazym® (DE); Lyopase® (BE); Mezym® (DE, RO, RU); Multanzim® (TR); Neo-Pancreatinum® (PL); Neo-Panpur® (HU); Nutrizym® (DE, GB, IE); Opti-Free® (BG, BR); Optifree® (MX); Ozym® (DE); Panaze® (SI); Pancrease® (BR, CZ, ES, IE, MX, NL, NO); Pancreatina II MK® (CO); Pancreatin® (RU); Pancrecura® (AR); Pancreolan® (CZ); Pancrex® (GB, NZ); Pancrex V® (GB); Pancrin® (AT); Pancrotanon® (IT); Pangrol® (CZ, DE, HU, PL); Pankrease HL® (ZA); Pankreatan® (DE); Pankreatin Laves® (DE); Pankreatin Mikro-ratiopharm® (DE); Pankreatin Rosco® (DK, SE); Pankreatin Stada® (DE); Pankreatin® (YU); Pankreoflat® (BR, IN, PT); Pankreon® (AT, BR, DE, DK, FI, NO, SE, TR); Pankreozym® (AR); Panpeptal® (DE); Panpur® (DE); Panzynorm® (AT, CZ, DE, IN, SI); Panzytrat® (BR, CH, CO, CZ, DE, HU, LU, NL, NZ, PL, RU); Polyzym® (BR); Selecto® (MX); Suzyme® (BD); Unexym® (DE); Viokase® (AU, LU, NZ, ZA); Zymet® (BD)

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