Penicillin V Potassium

Pronunciation

(pen i SIL in vee poe TASS ee um)

U.S. Brand Names

Veetids®

Synonyms

Pen VK; Phenoxymethyl Penicillin

Generic Available

Yes

Canadian Brand Names

Apo-Pen VK®; Nadopen-V®; Novo-Pen-VK; Nu-Pen-VK; PVF® K

Use

Treatment of infections caused by susceptible organisms involving the respiratory tract, otitis media, sinusitis, skin, and urinary tract; prophylaxis in rheumatic fever

Use - Dental

Antibiotic of first choice in treatment of common orofacial infections caused by aerobic gram-positive cocci and anaerobes. These orofacial infections include cellulitis, periapical abscess, periodontal abscess, acute suppurative pulpitis, oronasal fistula, pericoronitis, osteitis, osteomyelitis, postsurgical and post-traumatic infection. This agent is no longer recommended for dental procedure prophylaxis.

Pregnancy Risk Factor

Lactation

Enters breast milk (other penicillins are compatible with breast-feeding)

Contraindications

Hypersensitivity to penicillin or any component of the formulation

Warnings/Precautions

Use with caution in patients with severe renal impairment (modify dosage), history of seizures, or hypersensitivity to cephalosporins

Adverse Reactions

>10%: Gastrointestinal: Mild diarrhea, vomiting, nausea, oral candidiasis

<1%: Convulsions, fever, hemolytic anemia, positive Coombs' reaction, acute interstitial nephritis, hypersensitivity reactions, anaphylaxis

Overdosage/Toxicology

Symptoms of penicillin overdose include neuromuscular hypersensitivity (eg, agitation, hallucinations, asterixis, encephalopathy, confusion, and seizures). Electrolyte imbalance may occur if the preparation contains potassium or sodium salts, especially in renal failure. Hemodialysis may be helpful to aid in removal of the drug from blood; otherwise, treatment is supportive or symptom-directed.

Drug Interactions

Aminoglycosides: May be synergistic against selected organisms

Methotrexate: Penicillins may increase the exposure to methotrexate during concurrent therapy; monitor.

Oral contraceptives: Anecdotal reports suggesting decreased contraceptive efficacy with penicillins have been refuted by more rigorous scientific and clinical data.

Probenecid, disulfiram: May increase penicillin levels

Tetracyclines: May decrease penicillin effectiveness

Warfarin: Effects of warfarin may be increased

Ethanol/Nutrition/Herb Interactions

Food: Decreases drug absorption rate; decreases drug serum concentration.

Stability

Refrigerate suspension after reconstitution; discard after 14 days

Mechanism of Action

Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin binding proteins (PBPs); which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

Pharmacodynamics/Kinetics

Absorption: 60% to 73%

Distribution: Enters breast milk

Protein binding, plasma: 80%

Half-life elimination: 30 minutes; prolonged with renal impairment

Time to peak, serum: 0.5-1 hour

Excretion: Urine (as unchanged drug and metabolites)

Dosage

Oral:

Systemic infections:

Children <12 years: 25-50 mg/kg/day in divided doses every 6-8 hours; maximum dose: 3 g/day

Children 12 years and Adults: 125-500 mg every 6-8 hours

Prophylaxis of pneumococcal infections:

Children <5 years: 125 mg twice daily

Children 5 years and Adults: 250 mg twice daily

Prophylaxis of recurrent rheumatic fever:

Children <5 years: 125 mg twice daily

Children 5 years and Adults: 250 mg twice daily

Dosing interval in renal impairment: Clcr<10 mL/minute: Administer 250 mg every 6 hours

Administration

Administer on an empty stomach to increase oral absorption

Monitoring Parameters

Periodic renal and hematologic function tests during prolonged therapy; monitor for signs of anaphylaxis during first dose

Test Interactions

False-positive or negative urinary glucose determination using Clinitest®; positive Coombs' [direct]; false-positive urinary and/or serum proteins

Dietary Considerations

Take on an empty stomach 1 hour before or 2 hours after meals.

Patient Education

Inform prescriber of all prescriptions, OTC medications, or herbal products you are taking, and any allergies you have. Do not take any new medication during therapy unless approved by prescriber. Take as directed at intervals around-the-clock, preferable on an empty stomach (1 hour before or 2 hours after a meal). Take entire prescription; do not skip doses or discontinue without consulting prescriber. Take a missed dose as soon as possible. If almost time for next dose, skip the missed dose and return to your regular schedule. Do not take a double dose. Maintain adequate hydration (2-3 L/day of fluids) unless instructed to restrict fluid intake. If you have diabetes, drug may cause false test results with Clinitest®, consult prescriber for alternative method of glucose monitoring. May cause nausea or vomiting (small, frequent meals, frequent mouth care, chewing gum, or sucking lozenges may help); or diarrhea (buttermilk, boiled milk, or yogurt may help). Report persistent adverse effects; signs of opportunistic infection (eg, fever, chills, unhealed sores, white plaques in mouth or vagina, purulent vaginal discharge, fatigue); or signs of hypersensitivity reaction (rash, hives, itching, swelling of lips, tongue, mouth, or throat).

Additional Information

0.7 mEq of potassium per 250 mg penicillin V; 250 mg equals 400,000 units of penicillin

Dental Health: Effects on Dental Treatment

Key adverse event(s) related to dental treatment: Oral candidiasis (prolonged use).

Dental Health: Vasoconstrictor/Local Anesthetic Precautions

No information available to require special precautions

Mental Health: Effects on Mental Status

Penicillins reported to cause apprehension, illusions, hallucinations, depersonalization, agitation, insomnia, and encephalopathy

Mental Health: Effects on Psychiatric Treatment

None reported

Dosage Forms

Note : 250 mg = 400,000 units

Powder for oral solution: 125 mg/5 mL (100 mL, 200 mL); 250 mg/5 mL (100 mL, 200 mL)

Tablet: 250 mg, 500 mg

References

Dajani AS, Bisno AL, Chung KJ, et al, "Prevention of Rheumatic Fever. A Statement for Health Professionals by the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, The American Heart Association," Pediatr Infect Dis J , 1989, 8(5):263-6.

Wynn RL and Bergman SA, "Antibiotics and Their Use in the Treatment of Orofacial Infections, Part I and Part II," Gen Dent , 1994, 42(5):398-402, 498-502.

International Brand Names

Apo-Pen VK® (CA); Nadopen-V® (CA); Novo-Pen-VK (CA); Nu-Pen-VK (CA); PVF® K (CA)

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