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Pronunciation:

(pra MOKS een & hye droe KOR ti sone)

U.S. Brand Names:

Analpram-HC®; Enzone®; Epifoam®; Pramosone®; ProctoFoam®-HC; Zone-A®; Zone-A Forte®

Synonyms:

Hydrocortisone and Pramoxine

Generic Available:

Canadian Brand Names:

Pramox® HC; Proctofoam™-HC

Use:

Relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses

Pregnancy Risk Factor:

Pregnancy Implications:

Refer to Hydrocortisone monograph.

Contraindications:

Hypersensitivity to pramoxine, hydrocortisone, or any component of the formulation

Warnings/Precautions:

May cause suppression of hypothalamic-pituitary-adrenal (HPA) axis, particularly in younger children, application to large surface area, or with use of occlusive dressings. In case of HPA axis suppression, withdrawal and discontinuation should be done slowly.

Adverse Reactions:

See individual agents.

Drug Interactions:

Hydrocortisone: Substrate of CYP3A4 (minor); Induces CYP3A4 (weak)

Also see individual agents.

Stability:

Store at controlled room temperature of 15°C to 30°C (59°F to 86°F).

Pharmacodynamics/Kinetics:

See individual agents.

Dosage:

Topical/rectal: Apply to affected areas 3-4 times/day

Administration:

When using rectally, the special applicator should be used, the aerosol container should not be placed in the rectum; for local application the foam can be placed on a tissue first.

Patient Education:

When using rectally, the special applicator should be used, the aerosol container should not be placed in the rectum; for local application the foam can be placed on a tissue first

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

None reported

Mental Health: Effects on Psychiatric Treatment:

None reported

Dosage Forms:

Cream, topical:

Analpram-HC®: Pramoxine hydrochloride 1% and hydrocortisone acetate 1% (30 g); pramoxine hydrochloride 1% and hydrocortisone acetate 2.5% (30 g)

Enzone®: Pramoxine hydrochloride 1% and hydrocortisone acetate 1% (30 g)

Pramosone®: Pramoxine hydrochloride 1% and hydrocortisone acetate 1% (30 g, 60 g); pramoxine hydrochloride 1% and hydrocortisone acetate 2.5% (30 g, 60 g)

Foam, rectal (ProctoFoam®-HC): Pramoxine hydrochloride 1% and hydrocortisone acetate 1% (10 g)

Foam, topical (Epifoam®): Pramoxine hydrochloride 1% and hydrocortisone acetate 1% (10 g)

Lotion, topical:

Analpram-HC®: Pramoxine hydrochloride 1% and hydrocortisone 2.5% (60 mL)

Pramosone®: Pramoxine hydrochloride 1% and hydrocortisone 1% (60 mL, 120 mL, 240 mL); pramoxine hydrochloride 1% and hydrocortisone 2.5% (60 mL, 120 mL)

Zone-A®: Pramoxine hydrochloride 1% and hydrocortisone 1% (60 mL)

Zone-A Forte®: Pramoxine hydrochloride 1% and hydrocortisone 2.5% (60 mL)

Ointment, topical (Pramosone®): Pramoxine hydrochloride 1% and hydrocortisone 1% (30 g); pramoxine hydrochloride 1% and hydrocortisone 2.5% (30 g)

International Brand Names:

Pramox® HC (CA); Proctofoam™-HC (CA)

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