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Pronunciation:

(pred NIS oh lone & jen ta MYE sin)

U.S. Brand Names:

Pred-G®

Synonyms:

Gentamicin and Prednisolone

Generic Available:

Use:

Treatment of steroid responsive inflammatory conditions and superficial ocular infections due to microorganisms susceptible to gentamicin

Pregnancy Risk Factor:

Lactation:

Excretion in breast milk unknown/not recommended

Contraindications:

Hypersensitivity to gentamicin, prednisolone, other aminoglycosides or corticosteroids, or any component of the formulation; viral disease of the cornea and conjunctiva (including epithelia herpes simplex keratitis, vaccinia, varicella); mycobacterial or fungal infection of the eye; uncomplicated removal of a corneal foreign body

Warnings/Precautions:

Prolonged use of corticosteroids may result in glaucoma; damage to the optic nerve, defects in visual acuity and fields of vision, and posterior subcapsular cataract formation may occur. Prolonged use of corticosteroids may increase the incidence of secondary ocular infection or mask acute infection (including fungal infections); may prolong or exacerbate ocular viral infections; use following cataract surgery may delay healing or increase the incidence of bleb formation.

Adverse Reactions:

Frequency not defined.

Dermatologic: Delayed wound healing

Local: Burning, stinging

Ocular: Intraocular pressure increased, glaucoma, superficial punctate keratitis, optic nerve damage (infrequent), posterior subcapsular cataract formation

Miscellaneous: Secondary infection

Drug Interactions:

Prednisolone: Substrate of CYP3A4 (minor); Inhibits CYP3A4 (weak)

Also see individual agents.

Pharmacodynamics/Kinetics:

See individual agents.

Dosage:

Ophthalmic: Children and Adults:

Ointment: Apply ¹/2 inch ribbon in the conjunctival sac 1-3 times/day

Suspension: 1 drop 2-4 times/day; during the initial 24-48 hours, the dosing frequency may be increased if necessary up to 1 drop every hour

Administration:

Ophthalmic:

Ointment: For topical application into the conjunctival sac

Suspension: For topical application to the eye only; shake suspension well before using; do not inject subconjunctivally or introduce into the anterior chamber of the eye

Patient Education:

Shake suspension well; to avoid contamination, do not touch tip of container to any surface

Nursing Implications:

Monitor intraocular pressure with use >10 days

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

None reported

Mental Health: Effects on Psychiatric Treatment:

None reported

Dosage Forms:

Ointment, ophthalmic: Prednisolone acetate 0.6% and gentamicin sulfate 0.3% (3.5 g)

Suspension, ophthalmic: Prednisolone acetate 1% and gentamicin sulfate 0.3% (2 mL, 5 mL, 10 mL) [contains benzalkonium chloride]

References

Samples JR and Meyer SM, "Use of Ophthalmic Medications in Pregnant and Nursing Women,"Am J Ophthalmol, 1988, 106(5):616-23.

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