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Pronunciation:

(sye METH i kone)

U.S. Brand Names:

Alka-Seltzer® Gas Relief [OTC]; Baby Gasz [OTC]; Flatulex® [OTC]; Gas-X® [OTC]; Gas-X® Extra Strength [OTC]; Genasyme® [OTC]; Mylanta® Gas [OTC]; Mylanta® Gas Maximum Strength [OTC]; Mylicon® Infants [OTC]; Phazyme® Quick Dissolve [OTC]; Phazyme® Ultra Strength [OTC]

Synonyms:

Activated Dimethicone; Activated Methylpolysiloxane

Generic Available:

Yes: Tablet, suspension

Canadian Brand Names:

Ovol®; Phazyme™

Use:

Relieves flatulence and functional gastric bloating, and postoperative gas pains

Pregnancy Risk Factor:

Contraindications:

Hypersensitivity to simethicone or any component of the formulation

Adverse Reactions:

No data reported

Drug Interactions:

No data reported

Ethanol/Nutrition/Herb Interactions:

Food: Avoid carbonated beverages and gas-forming foods.

Stability:

Protect from light

Mechanism of Action:

Decreases the surface tension of gas bubbles thereby disperses and prevents gas pockets in the GI system

Dosage:

Oral:

Infants: 20 mg 4 times/day

Children <12 years: 40 mg 4 times/day

Children >12 years and Adults: 40-120 mg after meals and at bedtime as needed, not to exceed 500 mg/day

Administration:

Shake oral suspension (drops) before using; mix with water, infant formula, or other liquids.

Dietary Considerations:

Should be taken after meals.

Patient Education:

Some tablets may be chewed thoroughly before swallowing, follow with a glass of water

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

None reported

Mental Health: Effects on Psychiatric Treatment:

None reported

Dosage Forms:

Softgels:

Alka-Seltzer® Gas Relief, Gas-X® Extra Strength, Mylanta® Gas Maximum Strength: 125 mg

Phazyme® Ultra Strength: 180 mg

Suspension, oral drops: 40 mg/0.6 mL (30 mL)

Baby Gasz, Genasyme®: 40 mg/0.6 mL (30 mL)

Flatulex®: 40 mg/0.6 mL (30 mL) [fruit flavor]

Mylicon® Infants: 40 mg/0.6 mL (30 mL) [alcohol free; contains sodium benzoate; available in a non-staining formula]

Tablet, chewable: 80 mg, 125 mg

Gas-X®: 80 mg [peppermint crème or sodium free cherry crème flavor]

Gas-X® Extra Strength: 125 mg [peppermint crème or cherry crème flavor]

Genasyme®: 80 mg

Mylanta® Gas: 80 mg [mint flavor]

Mylanta® Gas Extra Strength: 125 mg [cherry and mint flavors]

Phazyme® Quick Dissolve: 125 mg [contains 0.4 mg phenylalanine (as aspartame)/tablet; mint flavor]

International Brand Names:

Ovol® (CA); Phazyme™ (CA)

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