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Pronunciation:

(sul KON a zole)

U.S. Brand Names:

Exelderm®

Synonyms:

Sulconazole Nitrate

Generic Available:

Canadian Brand Names:

Exelderm®

Use:

Treatment of superficial fungal infections of the skin, including tinea cruris (jock itch), tinea corporis (ringworm), tinea versicolor, and possibly tinea pedis (athlete's foot, cream only)

Pregnancy Risk Factor:

Lactation:

Excretion in breast milk unknown/use caution

Contraindications:

Hypersensitivity to sulconazole or any component of the formulation

Warnings/Precautions:

Use with caution in nursing mothers; for external use only

Adverse Reactions:

1% to 10%:

Dermatologic: Itching

Local: Burning, stinging, redness

Drug Interactions:

Inhibits CYP1A2 (weak), 2A6 (weak), 2C8/9 (weak), 2C19 (weak), 2D6 (weak), 2E1 (weak), 3A4 (weak)

No drug interaction data reported.

Mechanism of Action:

Substituted imidazole derivative which inhibits metabolic reactions necessary for the synthesis of ergosterol, an essential membrane component. The end result is usually fungistatic; however, sulconazole may act as a fungicide in Candida albicans and parapsilosis during certain growth phases.

Pharmacodynamics/Kinetics:

Absorption: Topical: ~8.7% percutaneously

Excretion: Primarily urine

Dosage:

Adults: Topical: Apply a small amount to the affected area and gently massage once or twice daily for 3 weeks (tinea cruris, tinea corporis, tinea versicolor) to 4 weeks (tinea pedis).

Patient Education:

For external use only; avoid contact with eyes; if burning or irritation develops, notify physician

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

None reported

Mental Health: Effects on Psychiatric Treatment:

None reported

Dosage Forms:

Cream, as nitrate: 1% (15 g, 30 g, 60 g)

Solution, topical, as nitrate: 1% (30 mL)

International Brand Names:

Exelderm® (CA, GB, HK, IE, TR); Fulcol® (DO); Minot® (AR); Myk 1® (BE, LU); Myk® (FR, NL)

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