Home > Medical Reference > Encyclopedia (English)

Please install flash player to see this video.

Hospital Virtual Tour

Related Content

Pronunciation:

(ter KONE a zole)

U.S. Brand Names:

Terazol® 3; Terazol® 7

Synonyms:

Triaconazole

Generic Available:

Canadian Brand Names:

Terazol®

Use:

Local treatment of vulvovaginal candidiasis

Pregnancy Risk Factor:

Lactation:

Excretion in breast milk unknown/not recommended

Contraindications:

Hypersensitivity to terconazole or any component of the formulation

Warnings/Precautions:

Should be discontinued if sensitization or irritation occurs. Microbiological studies (KOH smear and/or cultures) should be repeated in patients not responding to terconazole in order to confirm the diagnosis and rule out other other pathogens.

Adverse Reactions:

1% to 10%:

Central nervous system: Fever, chills

Gastrointestinal: Abdominal pain

Genitourinary: Vulvar/vaginal burning, dysmenorrhea

<1% (Limited to important or life-threatening): Vulvar itching, soreness, edema, or discharge; polyuria; burning or itching of penis of sexual partner; flu-like syndrome

Drug Interactions:

No data reported

Stability:

Store at room temperature of 13°C to 30°C (59°F to 86°F).

Mechanism of Action:

Triazole ketal antifungal agent; involves inhibition of fungal cytochrome P450. Specifically, terconazole inhibits cytochrome P450-dependent 14-alpha-demethylase which results in accumulation of membrane disturbing 14-alpha-demethylsterols and ergosterol depletion.

Pharmacodynamics/Kinetics:

Absorption: Extent of systemic absorption after vaginal administration may be dependent on presence of a uterus; 5% to 8% in women who had a hysterectomy versus 12% to 16% in nonhysterectomy women

Dosage:

Adults: Female:

Terazol® 3 vaginal cream: Insert 1 applicatorful intravaginally at bedtime for 3 consecutive days

Terazol® 7 vaginal cream: Insert 1 applicatorful intravaginally at bedtime for 7 consecutive days

Terazol® 3 vaginal suppository: Insert 1 suppository intravaginally at bedtime for 3 consecutive days

Patient Education:

Complete full course of therapy as directed. Insert vaginally as directed by prescriber or see package insert. Sexual partner may experience irritation of penis; best to refrain from intercourse during period of treatment. Suppositories may cause breakdown of rubber/latex products such as diaphragms; avoid concurrent use. Report persistent vaginal burning, itching, irritation, or discharge. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. Consult prescriber if breast-feeding.

Additional Information:

Watch for local irritation; assist patient in administration, if necessary; assess patient's ability to self-administer, may be difficult in patients with arthritis or limited range of motion

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

None reported

Mental Health: Effects on Psychiatric Treatment:

None reported

Dosage Forms:

Cream, vaginal:

Terazol® 7: 0.4% (45 g) [packaged with measured-dose applicator]

Terazol® 3: 0.8% (20 g) [packaged with measured-dose applicator]

Suppository, vaginal (Terazol® 3): 80 mg (3s) [may contain coconut and/or palm kernel oil]

International Brand Names:

Fungistat® (CO, MX); Gyno Fungistat® (BR); Gyno Fungix® (BR); Gyno-Terazol® (BE, CH, CZ, LU, NL); Terazol® (CA, ZA)

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.