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Pronunciation:

(tye oh KONE a zole)

U.S. Brand Names:

1-Day™ [OTC]; Vagistat®-1 [OTC]

Generic Available:

Use:

Local treatment of vulvovaginal candidiasis

Pregnancy Risk Factor:

Lactation:

Excretion in breast milk unknown/not recommended

Contraindications:

Hypersensitivity to tioconazole or any component of the formulation

Warnings/Precautions:

For vaginal use only. Petrolatum-based vaginal products may damage rubber or latex condoms or diaphragms. Separate use by 3 days.

Adverse Reactions:

Frequency not defined.

Central nervous system: Headache

Gastrointestinal: Abdominal pain

Dermatologic: Burning, desquamation

Genitourinary: Discharge, dyspareunia, dysuria, irritation, itching, nocturia, vaginal pain, vaginitis, vulvar swelling

Drug Interactions:

Inhibits CYP1A2 (weak), 2A6 (weak), 2C8/9 (weak), 2C19 (weak), 2D6 (weak), 2E1 (weak)

No drug interaction data reported.

Stability:

Store at room temperature.

Mechanism of Action:

A 1-substituted imidazole derivative with a broad antifungal spectrum against a wide variety of dermatophytes and yeasts, including Trichophyton mentagrophytes, T. rubrum, T. erinacei, T. tonsurans, Microsporum canis, Microsporum gypseum, and Candida albicans. Both agents appear to be similarly effective against Epidermophyton floccosum.

Pharmacodynamics/Kinetics:

Onset of action: Some improvement: Within 24 hours; Complete relief: Within 7 days

Absorption: Intravaginal: Systemic (small amounts)

Distribution: Vaginal fluid: 24-72 hours

Excretion: Urine and feces

Dosage:

Adults: Vaginal: Insert 1 applicatorful in vagina, just prior to bedtime, as a single dose

Administration:

Insert high into vagina

Patient Education:

Consult with healthcare provider if treating a vaginal yeast infection for the first time. Insert high into the vagina. Refrain from intercourse during treatment. May interact with condoms and vaginal contraceptive diaphragms (ie, weaken latex); do not rely on these products for 3 days following treatment. Do not use tampons, douches, spermicides, or other vaginal products during treatment. Although product is used for a single day, relief from symptoms usually takes longer than 1 day. Report persistent (>3 days) vaginal burning, irritation, or discharge. Breast-feeding precaution: Breast-feeding is not recommended.

Dental Health: Effects on Dental Treatment:

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions:

No information available to require special precautions

Mental Health: Effects on Mental Status:

None reported

Mental Health: Effects on Psychiatric Treatment:

None reported

Dosage Forms:

Ointment, vaginal: 6.5% (4.6 g) [with applicator]

International Brand Names:

Conasyd® (BD); Deocil Fem® (AR); Dermo-Rest® (TR); Dermo-Trosyd® (TR); Gino Tralen® (BR); Ginotrosyd® (IT); Gino-Trosyd® (PT); Gyno-Trosyd® (CH, CO, EG, FI, FR, HK, PL, SG, TR, ZA); Honguil® (AR); Mykontral® (DE); Tinazol® (BR); Tiocan® (TR); Tioconazol Genfar® (EC); Tiomicol® (AR); Tralen® (BR); Trosderm® (ES); Trosid® (ES); Trosyd® (AR, AT, CH, CL, CO, EG, FI, FR, HK, ID, IT, PT, SG, TH, ZA); Trosyl® (GB, IE)

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