Home > Medical Reference > Complementary Medicine

Trandolapril and Verapamil


Pronunciation

 (tran DOE la pril & ver AP a mil)


U.S. Brand Names

 Tarka®


Synonyms

 Verapamil and Trandolapril


Generic Available

 No


Canadian Brand Names

 Tarka®


Use

 Combination drug for the treatment of hypertension, however, not indicated for initial treatment of hypertension; replacement therapy in patients receiving separate dosage forms (for patient convenience); when monotherapy with one component fails to achieve desired antihypertensive effect, or when dose-limiting adverse effects limit upward titration of monotherapy


Pregnancy Risk Factor

 C/D (2nd and 3rd trimesters)


Lactation

 Enters breast milk/contraindicated


Adverse Reactions

 See individual agents.


Drug Interactions

 Verapamil: Substrate of CYP1A2 (major), 2B6 (minor), 2C8/9 (minor), 2C19 (minor), 2E1 (minor), 3A4 (major); Inhibits CYP1A2 (weak), 2C8/9 (weak), 2D6 (weak), 3A4 (moderate)

Also see individual agents.


Pharmacodynamics/Kinetics

 See individual agents.


Dosage

 Dose is individualized


Patient Education

 See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. Do not breast-feed.


Cardiovascular Considerations

 Combination therapy for the treatment of hypertension should be individualized for each patient. Potential advantages for trandolapril and verapamil combination therapy may include improved compliance and synergistic reductions in blood pressure with an accompanied reduction in side effects. See Special Cardiovascular Considerations for individual agents.


Dental Health: Effects on Dental Treatment

 No significant effects or complications reported


Dental Health: Vasoconstrictor/Local Anesthetic Precautions

 No information available to require special precautions


Mental Health: Effects on Mental Status

 May cause dizziness, drowsiness, nervousness, or insomnia


Mental Health: Effects on Psychiatric Treatment

 May cause neutropenia; use caution with clozapine and carbamazepine; may decrease lithium clearance resulting in an increase in serum lithium levels and potential lithium toxicity; monitor serum lithium levels; concurrent use with low potency antipsychotics and TCAs may produce additive hypotensive effects; barbiturates may decrease verapamil serum concentrations; verapamil may increase carbamazepine serum concentrations


Dosage Forms

Tablet, combination [trandolapril component is immediate release, verapamil component is sustained release]:

Trandolapril 1 mg and verapamil hydrochloride 240 mg

Trandolapril 2 mg and verapamil hydrochloride 180 mg

Trandolapril 2 mg and verapamil hydrochloride 240 mg

Trandolapril 4 mg and verapamil hydrochloride 240 mg


References

Chobanian AV, Bakris GL, Black HR, et al, "The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 Report," JAMA , 2003, 289(19):2560-71.

"Consensus Recommendations for the Management of Chronic Heart Failure. On Behalf of the Membership of the Advisory Council to Improve Outcomes Nationwide in Heart Failure," Am J Cardiol , 1999, 83(2A):1A-38A.

Kaplan NM and Sever PS, "Combination Therapy: A Key to Comprehensive Patient Care," Am J Hypertens , 1997, 10(7 Pt 2):127S.

Moser M and Black HR, "The Role of Combination Therapy in the Treatment of Hypertension," Am J Hypertens , 1998, 11(6 Pt 2):73S-8S, 95S-100S.


International Brand Names

 Tarka® (CA)


A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is the first of its kind, requiring compliance with 53 standards of quality and accountability, verified by independent audit. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial process . A.D.A.M. is also a founding member of Hi-Ethics (www.hiethics.com) and subscribes to the principles of the Health on the Net Foundation (www.hon.ch).

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997-2007 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
adam.com