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Ewing's Family of Tumors

What is Ewing's family of tumors?
Ewing's family of tumors (EFT) refers to a particular type of tumor that is found in different types of tissue. About 150 children and adolescents are diagnosed with EFT in the U.S. each year. It accounts for about 5 percent of all bone tumors in children.

When the tumor was first identified in the 1920s, it was called Ewing's tumor and thought to occur only in bone tissue. Later, the same type of tumor was found in soft tissues and named extraosseous (not in bone) Ewing's (EOE). Another tumor very similar to Ewing's, primitive neuroectodermal tumor (PNET), is a rare cancer found in both soft tissue and bone. 

Today, a tumor from this group is referred to as being from Ewing's family of tumors (EFT) or a tumor of the Ewing's family (TEF). Ewing's tumor of the bone is the most prevalent, followed by EOE and then PNET. 

Although they can occur at any age, Ewing's tumors occur most often in adolescents in their early teens. Usually, they occur in the middle of the long bones, but may also occur in the pelvic bones or in the bones of the chest.

What are the causes of Ewing's family of tumors?
The exact cause of EFT is not known, but it is believed to be due to changes that occur in the chromosomes. Other theories and associations have been suggested as risk factors.

What are the risk factors for Ewing's family of tumors?
Suggested risk factors for EFT include:

  • race - occurs most frequently in Caucasians
  • gender - occurs slightly more often in boys
  • age - 64 percent of patients are between the ages of 10 and 20; 27 percent of patients  under age 10
 
FOR MORE INFORMATION
Greenebaum Cancer Center:
Ewing's Family of Tumors

Visit the Greenebaum Cancer Center Overviews section of our site for more information about this disease.
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What is a risk factor?

A risk factor is anything that may increase a person's chance of developing a disease. It may be an activity, such as smoking or diet, family history, or many other things. Different diseases have different risk factors.

Although these factors can increase a person's risk, they do not necessarily cause the disease. Some people with one or more risk factors never develop the disease, while others develop the disease and have no known risk factors.

But, knowing your risk factors to any disease can help to guide you to take appropriate actions, including changing behaviors and being clinically monitored for the disease.

What are symptoms of Ewing's family of tumors?
The following are the most common symptoms for Ewing's family of tumors, however, each individual may experience symptoms differently. Signs and symptoms may include:

  • pain from the spread of cancer cells or from fractures caused by the disease
  • swelling in the tumor location
  • a tumor that is soft and warm to the touch
  • bumps and bruises in tumor location
  • fever in children

The symptoms of EFT may resemble other bone cancer problems, such as osteosarcoma. Consult your physician for a diagnosis.

How are Ewing's family of tumors diagnosed?
In addition to a complete medical history and physical examination, diagnostic procedures for Ewing's family of tumors may include:

imaging procedures, such as..
  • x-ray
  • computed tomography (CT or CAT)
  • magnetic resonance imaging (MRI)
  • radionuclide bone scan
laboratory blood tests

biopsy to remove tissue, such as...

  • needle biopsy
  • open biopsy
bone marrow biopsy

bone marrow aspiration

Treatment for Ewing's family of tumors:
Your physician(s) will determine specific treatment for Ewing's family of tumors based on:

  • your overall health and medical history
  • extent of the disease
  • your tolerance for specific medications, procedures, or therapies
  • expectations for the course of the disease
  • your opinion or preference

Treatments may include...

  • chemotherapy
  • surgery
  • radiation therapy
  • bone marrow transplantation
  • peripheral blood stem cell transplantation


This content was last reviewed by a University of Maryland Medicine expert on
May 14, 2003


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