Dermatology

Skin Inflammation (Rashes)

Toxic Epidermal Necrolysis

What is toxic epidermal necrolysis?

Toxic epidermal necrolysis is a life-threatening skin disorder characterized by a blistering and peeling of the top layer of skin. This disorder can be caused by a drug reaction -- most often penicillin -- or another disease. About one-third of all diagnosed cases of toxic epidermal necrolysis are a result of unknown causes.

What are the symptoms of toxic epidermal necrolysis?

Toxic epidermal necrolysis can cause the skin to peel off in sheets, leaving large areas that look scalded. The loss of skin causes fluids and salts to ooze from the raw, damaged areas which can easily become infected. The following are the most common symptoms of toxic epidermal necrolysis. However, each person may experience symptoms differently:

a painful, red area that spreads quickly
the top layer of skin may peel without blistering
scalded-looking raw areas of flesh
discomfort
fever
condition spread to eyes, mouth, and genitals

The symptoms of toxic epidermal necrolysis may resemble other dermatologic conditions. Consult a physician for diagnosis.

Treatment for toxic epidermal necrolysis:
The progression of the disease happens fast, usually within three days. Treatment usually includes hospitalization, often in the burn unit. If a medication is causing the skin reaction, the patient is immediately taken off the medication. Specific treatment for toxic epidermal necrolysis will be determined by your physician based on:

your overall health, age, and medical history
severity of the condition
your tolerance of specific medications, procedures, or therapies
your opinion or preference

Treatment may include one, or several, of the following:

isolation to prevent infection
protective bandages
intravenous fluid and electrolytes
antibiotics

This page was last updated on: January 31, 2008.

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