Jeffrey D. Hasday, M.D.

Professor of Medicine, Pathology, and Biochemistry and Molecular Biology
Head, Division of Pulmonary and Critical Care Medicine

Department: Division
Medicine: Pulmonary and Critical Care Medicine

Special Interests: Interstitial Lung Disease; Asthmas; Acute Lung Injury/ ARDS; Sepsis

Medical Degree: University of Rochester

Residency: Rochester General Hospital

Fellowship: University of Michigan Medical Center, Pulmonary and Critical Care Medicine; University of Rochester, Clinical Pharmacology

Certification: Internal Medicine; Pulmonary Diseases; Critical Care Medicine

Biography:

• Head, Pulmonary and Critical Care Div., University of Maryland School Medicine, Baltimore, MD
• Associate Director, University of Maryland Mucosal Biology Research Center
• Director, Cytokine Core Laboratory
• Chairman, University of Maryland Research Affairs Advisory Committee

Research Interest:

• Innate immunity in the lung
• Mechanisms of acute lung injury
• Heat shock/stress pathways in the lung
• Effects of fever and hypothermia on innate immunity
• Cytokine gene regulation
• Mechanisms of sepsis/multiorgan injury
• Bacterial endotoxin in COPD and asthma

Dr. Hasday is internationally recognized for work on the immunomodulatory effects of physiologically-relevant changes in temperature. His bedside-to-bench-to-bedside research on the basic mechanisms through which febrile-range hyperthermia (FRH) modulates host defenses has produced a substantial body of work in this area in the last decade.

He recently reported that FRH dramatically increases pulmonary oxygen therapy. This work spans the range from the basic molecular and cell biology to whole animal models and clinical trials. If confirmed in humans, this will lead to a practice-altering ARDS study to originate from the Division. Drs. Hasday and Singh have advanced a concept that fever borrows some heat shock mechanisms, including the central heat-shock-activated transcription factor, Heat Shock Factor-1 (HSF-1), which act in different ways at febrile- and heat-shock-temperatures. His studies in HSF-1 knockout mice showing that heat shock increases lung inflammation and injury may lead to new therapeutic modalities.

Dr. Hasday has also showed that clinically-relevant hypothermia prolongs expression of the proinflammatory cytokines TNFa and IL-1? in monocyte cultures and blocks apoptosis in epithelial cells. He has recently shown that this effect is even more global in that activation of the pivotal transcription factor, NFkB, is prolonged in hypothermic cell. Since NFkB activates both proinflammatory cytokine genes and anti-apoptosis genes, this exciting finding may explain both the cytoprotective effects of hypothermia as well as its association with higher circulating cytokine levels and inreased mortality in patients with sepsis.

Dr. Hasday has also that the bronchoalveolar compartment of the lung is converted from an endotoxin-insensitive to an endotoxin-sensitive environment by the leak of the endotoxin accessory molecule, LPS-Binding Protein from the circulation. Dr. Hasday also showed that cigarette smoke contains large amounts of biologically active endotoxin, representing a potential link between COPD and smoking and other environmental lung diseases attributable to inhaled endotoxin.

He is currently extending these studies with Drs. Matthew Fenton and Stefanie Vogel.

Current Research Funding:

• 04/00-09/05 VA Merit Review "Regulation of temperature dependent TNF? expression," $716,400 (direct costs), JD Hasday, Principal Investigator.
• 01/01-12/03 National Arthritis Foundation grant: "The Role of Chemokines in the Pathogenesis of Interstitial Lung Disease," $100,000 (direct costs), JD Hasday, Principal Investigator.
• 03/03-02/07 National Institutes of Health RO1: "Mechanisms of Fever-Enhanced Hyperoxic Lung Injury" $1,250,000 (direct costs) JD Hasday, Principal Investigator.
• 04/02 - 03/07 National Institutes of Health R01 HL70155-01(Goldblum): "PTPmu Regulates Lung Endothelial Paracellular Pathway." $1,125,000 (direct costs) JD Hasday, co-investigator (10%).
• 04/03-03/09 National Institutes of Health RO1: "Mechanisms of HSF-1-mediated repression of TNF-alpha," $1,250,000 (direct costs) JD Hasday, Principal Investigator (pending).

Education:

• M.D. - University of Rochester School of Medicine (1979)
• House Staff Training: University of Rochester (1980-83)
• Fellowship Training (if applicable): Clinical Pharmacology, University of Rochester (1979-80); Pulmonary and Critical Care, University of Michigan (1983-86)
• Professor of Medicine, Univ of Maryland School of Medicine, Baltimore, MD
• Professor of Pathology, Univ of Maryland School of Medicine, Baltimore, MD
• Professor of Biochemistry&Molecular Biology, U. Maryland Sch. Medicine, Baltimore, MD

Contact Information:
1-800-373-4111 (physicians only)
1-800-492-5538 (patients and general information)
1-410-328-8919 (news media only)