You should not use this medicine if you have had an allergic reaction to difenoxin, atropine, or if you have jaundice (yellowing of your skin or eyes). You should not use this medicine if you have diarrhea caused by certain kinds of food poisoning or diarrhea caused by using antibiotics. Do not give this medicine to a child under 2 years of age.
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Tell your doctor if you are using medicines that could make you drowsy such as sleeping pills, some cold or allergy medicine, strong pain killers, tranquilizers or muscle relaxants.
Avoid drinking alcohol while using this medicine. You may get too drowsy or sedated if you drink alcohol or use medicines that cause drowsiness with difenoxin/atropine.
Make sure your doctor knows if you are using a medicine called a monoamine oxidase (MAO) inhibitors. MAO inhibitors such as Parnate®, Marplan®, or Nardil® treat depression. Eldepryl® is used to treat Parkinson's disease. Using this medicine with a MAO inhibitor can cause severe high blood pressure.