You should not use this medicine if you have had an allergic reaction to dirithromycin or to similar medicines such as Zithromax®, Biaxin®, or erythromycin (EES®, E-Mycin®, ERYC®, and PCE® are some brand names of erythromycin).
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some patients have had serious heart problems when taking Seldane® or Hismanal® with erythromycin (a medicine that is similar to dirithromycin). It is important to tell your doctor if you are taking Seldane® or Hismanal® before you take dirithromycin.
Make sure your doctor knows if you are also taking theophylline, Halcion®, digoxin (Lanoxin®), blood thinners such as Coumadin®, or seizure medicines such as Dilantin®, Tegretol®, or Depakote®.